| Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab. | |
| | |
MedLine Citation:
|
PMID: 21665955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Pertuzumab, a human epidermal growth factor receptor (HER) 2 dimerization inhibitor, has demonstrated promising efficacy in combination with trastuzumab in patients with metastatic breast cancer. As HER signaling pathways are not only involved in oncogenesis, but also in myocardial homeostasis, an analysis of cardiac safety data was undertaken in a large group of patients treated with pertuzumab. PATIENTS AND METHODS: A complete database of patients treated with full-dose pertuzumab was used to describe the incidence of asymptomatic left ventricular systolic dysfunction (LVSD) and symptomatic heart failure (HF). RESULTS: Information for 598 unique patients was available for the current analysis. Of the patients treated with pertuzumab alone (n = 331) or pertuzumab in combination with a non-anthracycline-containing cytotoxic (n = 175) or trastuzumab (n = 93), 23 (6.9%), 6 (3.4%), and 6 (6.5%), respectively, developed asymptomatic LVSD and 1 (0.3%), 2 (1.1%), and 1 (1.1%), respectively, displayed symptomatic HF. None of the 15 patients receiving both pertuzumab and erlotinib demonstrated LVSD. CONCLUSIONS: Patients treated with pertuzumab experienced relatively low levels of asymptomatic LVSD or symptomatic HF. There was no notable increase in cardiac side-effects when pertuzumab was given in combination with other anticancer agents. |
| | |
Authors:
|
D Lenihan; T Suter; M Brammer; C Neate; G Ross; J Baselga |
Related Documents
:
|
6441765 - Lithium and lecithin treatment in alzheimer's disease: a pilot study. 12526015 - Selective use of transthyretin and retinol-binding protein as markers in the postoperat... 21642865 - Anaplastic lymphoma kinase translocation: a predictive biomarker of pemetrexed in patie... 10063715 - Serum albumin concentration as a prognostic indicator for acute surgical patients. 8766255 - Pure red cell aplasia: clinical features and treatment results in 16 cases. 23411705 - Absent or extremely low neutrophil alkaline phosphatase activity levels in patients wit... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-06-10 |
Journal Detail:
|
Title: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Volume: 23 ISSN: 1569-8041 ISO Abbreviation: Ann. Oncol. Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-02-27 Completed Date: 2012-06-12 Revised Date: 2013-04-15 |
Medline Journal Info:
|
Nlm Unique ID: 9007735 Medline TA: Ann Oncol Country: England |
Other Details:
|
Languages: eng Pagination: 791-800 Citation Subset: IM |
Affiliation:
|
Department of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37232, USA. daniel.lenihan@vanderbilt.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibodies, Monoclonal, Humanized
/
adverse effects* Antineoplastic Agents / adverse effects* Clinical Trials, Phase II as Topic Heart / drug effects* Heart Failure / chemically induced, epidemiology* Humans Neoplasms / drug therapy* Ventricular Dysfunction, Left / chemically induced, epidemiology |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal, Humanized; 0/Antineoplastic Agents; 380610-27-5/pertuzumab |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Facilitation and Ca2+-dependent inactivation are modified by mutation of the Ca(v)1.2 channel IQ mot...
Next Document: Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcogl...