| Pontine cholinergic reticular mechanisms cause state-dependent changes in the discharge of parabrachial neurons. | |
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MedLine Citation:
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PMID: 8304534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study examined the hypothesis that cholinoceptive reticular mechanisms in the gigantocellular tegmental field (FTG) of the medial pontine reticular formation cause state-dependent changes in the discharge of parabrachial neurons. In chronically implanted, unanesthetized cats, extracellular recordings were made from nonrespiratory and respiratory neurons in the parabrachial nuclear complex (PBNC) during the natural sleep-wake cycle and during the rapid eye movement (REM) sleeplike state caused by FTG microinjection of carbachol or neostigmine. PBNC cells that increased discharge during natural REM sleep (REM-on cells) revealed similar increased discharge during the carbachol-induced REM sleeplike state (DCarb). Cells that decreased discharge in natural REM sleep (REM-off cells) displayed decreased discharge during both DCarb and the neostigmine-induced REM sleeplike states. The limited sample of parabrachial respiratory neurons revealed significantly diminished discharge during the cholinergically induced REM sleeplike state. Thus cholinoceptive mechanisms localized to specific regions of the pontine reticular formation can cause state-dependent changes in the firing rates of respiratory and nonrespiratory neurons in the PBNC. |
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Authors:
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K A Gilbert; R Lydic |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 266 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-03-09 Completed Date: 1994-03-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R136-50 Citation Subset: IM |
Affiliation:
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Department of Anesthesia, Pennsylvania State University, College of Medicine, Hershey 17033. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbachol / pharmacology Cats Electrophysiology Male Neostigmine / pharmacology Neurons / physiology Parasympathetic Nervous System / physiology* Pons / cytology, physiology* Respiratory Center / physiology Respiratory System / innervation Reticular Formation / physiology* Sleep Stages / drug effects, physiology Sleep, REM / physiology Wakefulness / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-40881/HL/NHLBI NIH HHS; HL-47749/HL/NHLBI NIH HHS; MH-18825/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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51-83-2/Carbachol; 59-99-4/Neostigmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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