Document Detail

Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity.
MedLine Citation:
PMID:  19429373     Owner:  NLM     Status:  MEDLINE    
AIMS OF THE STUDY: Fatty liver is the most common cause of abnormal liver function tests. We investigated the effect and its underlying mechanism of pomegranate flower (PGF), a traditional antidiabetic medicine, on fatty liver. MATERIALS AND METHODS: At the endpoint of treatment of male Zucker diabetic fatty (ZDF) rats with PGF extract (500 mg/kg, p.o. x 6 weeks), liver weight index, hepatic lipid contents (enzymatic colorimetric methods) and droplet accumulation (Oil Red O staining) were determined. Gene profiles (RT-PCR) were analyzed in the liver of ZDF rats and in human liver-derived HepG2 cell line. RESULTS: PGF-treated ZDF rats showed reduced ratio of liver weight to tibia length, hepatic triglyceride contents and lipid droplets. These effects were accompanied by enhanced hepatic gene expression of peroxisome proliferator-activated receptor (PPAR)-alpha, carnitine palmitoyltransferase-1 and acyl-CoA oxidase (ACO), and reduced stearoyl-CoA desaturase-1. In contrast, PGF showed minimal effects on expression of genes responsible for synthesis, hydrolysis or uptake of fatty acid and triglycerides. PGF treatment also increased PPAR-alpha and ACO mRNA levels in HepG2 cells. CONCLUSION: Our findings suggest that this Unani medicine ameliorates diabetes and obesity-associated fatty liver, at least in part, by activating hepatic expression of genes responsible for fatty acid oxidation.
Kevin Zhe-Yang Xu; Chenchen Zhu; Moon Sun Kim; Johji Yamahara; Yuhao Li
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Publication Detail:
Type:  Journal Article     Date:  2009-04-01
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  123     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  280-7     Citation Subset:  IM    
Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia.
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MeSH Terms
Carcinoma, Hepatocellular / metabolism
Cell Line, Tumor
Diabetes Mellitus, Experimental / complications
Diabetes Mellitus, Type 2 / complications*
Fatty Liver / etiology,  genetics,  prevention & control*
Gene Expression Regulation / drug effects
Liver Function Tests
Liver Neoplasms / metabolism
Obesity / complications
PPAR alpha / drug effects,  genetics
Plant Extracts / pharmacology*
Punicaceae / chemistry*
RNA, Messenger / drug effects,  metabolism
Rats, Zucker
Reg. No./Substance:
0/PPAR alpha; 0/Plant Extracts; 0/RNA, Messenger

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