Document Detail

Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling.
MedLine Citation:
PMID:  9038199     Owner:  NLM     Status:  MEDLINE    
The Schizosaccharomyces pombe cdc5 gene product is a cell cycle regulator that exerts its effects at the G2/M transition in fission yeast. We describe the cloning of a putative human transcription factor, pombe Cdc5-related protein (PCDC5RP), which bears significant homology to S. pombe Cdc5 and to expressed sequences in mouse, nematode, and budding yeast. PCDC5RP is expressed widely in normal adult human tissues and thus may have an important general function that has been preserved evolutionarily. PCDC5RP contains two tandem repeats of a helix-turn-helix DNA binding motif, four consensus nuclear localization signals, and a hydrophilic, proline-rich central region similar to the transcriptional activating domain in Myb family members. Remarkably, PCDC5RP moved rapidly from cytoplasm to nucleus upon serum stimulation of cultured cells. This movement correlated temporally with an increase in PCDC5RP phosphorylation. Thus, PCDC5RP is a presumed transcription factor that appears to transduce cytoplasmic signals to the nucleus upon serum stimulation.
H S Bernstein; S R Coughlin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  272     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-15     Completed Date:  1997-04-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5833-7     Citation Subset:  IM    
Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Cell Cycle Proteins / chemistry,  genetics,  metabolism*
Cloning, Molecular
Fungal Proteins / metabolism*
Molecular Sequence Data
Mutagenesis, Site-Directed
Schizosaccharomyces pombe Proteins
Transcription Factors / metabolism*
Grant Support
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Fungal Proteins; 0/Schizosaccharomyces pombe Proteins; 0/Transcription Factors; 0/cdc5 protein, S pombe

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