Document Detail


Polyvalent nucleic acid nanostructures.
MedLine Citation:
PMID:  21630678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polyvalent oligonucleotide-nanoparticle conjugates possess several unique emergent properties, including enhanced cellular uptake, high antisense bioactivity, and nuclease resistance, which hypothetically originate from the dense packing and orientation of oligonucleotides on the surface of the nanoparticle. In this Communication, we describe a new class of polyvalent nucleic acid nanostructures (PNANs), which are comprised of only cross-linked and oriented nucleic acids. We demonstrate that these particles are capable of effecting high cellular uptake and gene regulation without the need of a cationic polymer co-carrier. The PNANs also exhibit cooperative binding behavior and nuclease resistance properties.
Authors:
Joshua I Cutler; Ke Zhang; Dan Zheng; Evelyn Auyeung; Andrew E Prigodich; Chad A Mirkin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-06-01
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  133     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-15     Completed Date:  2011-09-29     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9254-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Transport
Cell Line, Tumor
DNA / chemistry*,  metabolism
Deoxyribonucleases / metabolism
Humans
Nanostructures / chemistry*
RNA / chemistry*,  metabolism
Ribonucleases / metabolism
Grant Support
ID/Acronym/Agency:
U54 CA151880/CA/NCI NIH HHS; U54 CA151880-01/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
63231-63-0/RNA; 9007-49-2/DNA; EC 3.1.-/Deoxyribonucleases; EC 3.1.-/Ribonucleases
Comments/Corrections

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