| Polyunsaturated fatty acids and neurotransmission in Caenorhabditis elegans. | |
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MedLine Citation:
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PMID: 16417487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in PUFA (polyunsaturated fatty acid) metabolism can cause mental retardation and cognitive impairment. However, it is still unclear why altered levels of PUFAs result in neuronal dysfunction. Recent studies on the nematode Caenorhabditis elegans suggest that PUFA depletion may cause cognitive impairment by compromising communication among neurons. Pharmacological and electrophysiological experiments showed that animals devoid of most PUFAs release abnormally low levels of neurotransmitters. In addition, ultrastructural analysis revealed that synapses in these mutants are severely depleted of synaptic vesicles. The conclusion of these studies is that PUFAs are required to maintain a normal pool of synaptic vesicles at pre-synaptic sites, thus ensuring efficient neurotransmission. |
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Authors:
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E Marza; G M Lesa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biochemical Society transactions Volume: 34 ISSN: 0300-5127 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-18 Completed Date: 2006-03-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 77-80 Citation Subset: IM |
Affiliation:
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MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior / physiology Caenorhabditis elegans / metabolism* Fatty Acids, Unsaturated / chemistry, metabolism* Molecular Structure Neurotransmitter Agents / metabolism Synapses / metabolism, ultrastructure Synaptic Transmission / physiology* Synaptic Vesicles / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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