| Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia. | |
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MedLine Citation:
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PMID: 19141698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The transcription factor 7-like 2 (TCF7L2) has been recently associated with diabetes risk, and it may exert its effect through metabolic syndrome (MetS)-related traits and be subjected to modification by environmental factors. We investigated the effect of single nucleotide polymorphisms (SNP), rs7903146 and rs12255372, within the TCF7L2 locus on postprandial lipemia and other MetS-related traits and their modulation by dietary fat. Data were collected from 1083 European Americans participating in the Genetics of Lipid Lowering Drugs and Diet Network Study. Carriers of the minor T allele at the C/T rs7903146 SNP had higher fasting plasma glucose (P = 0.012), lower homeostasis model assessment of beta cell function (P = 0.041), higher plasma VLDL (P = 0.035), and lower large LDL particle (P = 0.007) concentrations and higher risk of MetS (P = 0.011) than CC individuals. Moreover, we identified significant interactions between this SNP and PUFA intake modulating fasting VLDL particle concentrations (P = 0.016) and postprandial triglycerides (TG) (P = 0.028), chylomicrons (P = 0.025), total VLDL (P = 0.026), and large VLDL (P = 0.018) concentrations. Thus, only T allele carriers with a PUFA intake > or = 7.36% of energy had elevated fasting plasma VLDL concentrations and postprandial TG-rich lipoproteins. These variables did not differ in T allele carriers and noncarriers in the low-PUFA intake group. Moreover, these significant interactions were due exclusively to (n-6) PUFA intake. In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146 SNP and may predispose them to MetS, diabetes, and cardiovascular disease. |
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Authors:
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Daruneewan Warodomwichit; Donna K Arnett; Edmond K Kabagambe; Michael Y Tsai; James E Hixson; Robert J Straka; Michael Province; Ping An; Chao-Qiang Lai; Ingrid Borecki; Jose M Ordovas |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-01-13 |
Journal Detail:
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Title: The Journal of nutrition Volume: 139 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-19 Completed Date: 2009-03-24 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 439-46 Citation Subset: IM |
Affiliation:
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Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Diet Dietary Fats, Unsaturated Fatty Acids, Unsaturated / pharmacology* Female Gene Expression Regulation / physiology Genetic Variation Humans Hyperlipidemias / genetics, metabolism* Male Middle Aged Polymorphism, Single Nucleotide Postprandial Period / genetics, physiology* TCF Transcription Factors / genetics*, metabolism* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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DK075030/DK/NIDDK NIH HHS; HL-54776/HL/NHLBI NIH HHS; U01 HL72524/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats, Unsaturated; 0/Fatty Acids, Unsaturated; 0/TCF Transcription Factors; 0/Tcf7L2 transcription factor |
| Comments/Corrections | |
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