Document Detail

Polyunsaturated fatty acids and infant visual development: a critical appraisal of randomized clinical trials.
MedLine Citation:
PMID:  10102244     Owner:  NLM     Status:  MEDLINE    
At the Consensus and Controversies Conference held in Barcelona in November 1996, one of the sessions focused on an evaluation of the effects of dietary polyunsaturated fatty acids (PUFA) on infant visual development. The intervention trials in preterm and term infants were reviewed and discussed in detail. Results of these trials, particularly those in term infants, were inconsistent; much discussion occurred concerning the causes of these diverse results. We attempt to reflect, rather than report exactly, the discussion relating to these issues and address the clinical trials according to recently published guidelines for conduct and reporting of randomized clinical trials (RCT). Compared with these recent guidelines, the published papers of RCT involving PUFA and visual function are often incomplete, making it difficult to assess if we can have a high degree of confidence in the reported effects (or lack of effects). Despite this, valuable data relating to the effect of diet on the visual development of infants were obtained. Our evaluation of the trials to date suggests that the definitive answer to the degree to which dietary long-chain PUFA is likely to influence visual development may only be resolved with impeccably conducted RCT.
R A Gibson; M Makrides
Related Documents :
21273984 - Early postnatal hypotension is not associated with indicators of white matter damage or...
17120844 - Development of modal and amodal completion in infants.
1372234 - Stimulus rate-induced vep attenuation in preterm infants.
10102244 - Polyunsaturated fatty acids and infant visual development: a critical appraisal of rand...
9252434 - Disappearing suprarenal masses in fetuses and infants.
8267234 - Immunologic benefits of breast milk in relation to human milk banking.
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  34     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-06-10     Completed Date:  1999-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  IM    
Child Nutrition Research Centre, Flinders Medical Centre, Bedford Park (Adelaide), SA, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Fatty Acids, Unsaturated / administration & dosage*
Randomized Controlled Trials as Topic
Research Design
Vision, Ocular / physiology*
Reg. No./Substance:
0/Fatty Acids, Unsaturated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Polyunsaturated fatty acid status and neurodevelopment: a summary and critical analysis of the liter...
Next Document:  Statistical considerations in infant nutrition trials.