| Polyunsaturated fatty acids and epilepsy. | |
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MedLine Citation:
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PMID: 20608961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are dietary fatty acids that are involved in a myriad of physiologic processes in the brain. There is some evidence suggesting that PUFAs-and particularly omega-3 PUFAs-may have anticonvulsant effects, both in humans and in animals. In the present review, we assess the evidence related to the antiseizure properties of the n-3 PUFAs, discuss their possible mechanism(s) of action, and make recommendations for future clinical trials. In general, the available data from cell cultures and whole animal studies support the idea that the n-3 PUFAs have antiseizure properties. Future clinical trials involving the n-3 PUFAs should involve higher doses and longer periods of administration in order to definitively assess their possible antiseizure effects. |
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Authors:
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Ameer Y Taha; W McIntyre Burnham; Stéphane Auvin |
Publication Detail:
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Type: Journal Article; Review Date: 2010-07-01 |
Journal Detail:
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Title: Epilepsia Volume: 51 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2010-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 1348-58 Citation Subset: IM |
Copyright Information:
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Wiley Periodicals, Inc. © 2010 International League Against Epilepsy. |
Affiliation:
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Department of Pharmacology and Toxicology and the University of Toronto Epilepsy Research Program, Faculty of Medicine, University of Toronto, Toronto, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / therapeutic use* Brain / metabolism Epilepsy / drug therapy*, metabolism*, pathology Fatty Acids, Unsaturated / metabolism*, therapeutic use* Humans Models, Biological |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Fatty Acids, Unsaturated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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