Document Detail


Polyunsaturated fatty acids effect on serum triglycerides concentration in the presence of metabolic syndrome components. The Alaska-Siberia Project.
MedLine Citation:
PMID:  19766268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum fatty acids (FAs) have wide effects on metabolism: Serum saturated fatty acids (SFAs) increase triglyceride (TG) levels in plasma, whereas polyunsaturated fatty acids (PUFAs) reduce them. Traditionally, Eskimos have a high consumption of omega-3 fatty acids (omega3 FAs); but the Westernization of their food habits has increased their dietary SFAs, partly reflected in their serum concentrations. We studied the joint effect of serum SFAs and PUFAs on circulating levels of TGs in the presence of metabolic syndrome components. We included 212 men and 240 women (age, 47.9 +/- 15.7 years; body mass index [BMI], 26.9 +/- 5.3) from 4 villages located in Alaska for a cross-sectional study. Generalized linear models were used to build surface responses of TG as functions of SFAs and PUFAs measured in blood samples adjusting by sex, BMI, and village. The effects of individual FAs were assessed by multiple linear regression analysis, and partial correlations (r) were calculated. The most important predictors for TG levels were glucose tolerance (r = 0.116, P = .018) and BMI (r = 0.42, P < .001). Triglyceride concentration showed negative associations with 20:3omega6 (r = -0.16, P = .001), 20:4omega6 (r = -0.14, P = .005), 20:5omega3 (r = -0.17, P < .001), and 22:5omega3 (r = -0.26, P < .001), and positive associations with palmitic acid (r = 0.16, P < .001) and 18:3omega3 (r = 0.15, P < .001). The surface response analysis suggested that the effect of palmitic acid on TG is blunted in different degrees according to the PUFA chemical structure. The long-chain omega3, even in the presence of high levels of saturated fat, was associated with lower TG levels. Eicosapentaenoic acid (20:5omega3) had the strongest effect against palmitic acid on TG. The total FA showed moderate association with levels of TG, whereas SFA was positively associated and large-chain PUFA was negatively associated. The Westernized dietary habits among Eskimos are likely to change their metabolic profile and increase comorbidities related to metabolic disease.
Authors:
Juan C Lopez-Alvarenga; Sven O E Ebbesson; Lars O E Ebbesson; M Elizabeth Tejero; V Saroja Voruganti; Anthony G Comuzzie
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-09-18
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  59     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2009-12-15     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-92     Citation Subset:  IM    
Affiliation:
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227-5301, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alaska
Body Mass Index
Cross-Sectional Studies
Fatty Acids, Unsaturated / blood*
Female
Glucose Tolerance Test
Humans
Male
Metabolic Syndrome X / blood*
Middle Aged
Radioimmunoassay
Siberia
Triglycerides / blood*
Grant Support
ID/Acronym/Agency:
C06 RR017515/RR/NCRR NIH HHS; C06 RR017515-01A1/RR/NCRR NIH HHS; R01-47099//PHS HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Triglycerides
Comments/Corrections

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