| Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel. | |
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MedLine Citation:
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PMID: 17556656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vessel occlusion is the most frequent cause for impairment of local blood flow within the brain resulting in neuronal damage and is a leading cause of disability and death worldwide. Polyunsaturated fatty acids and especially alpha-linolenic acid improve brain resistance against cerebral ischemia. The purpose of the present study was to evaluate the effects of polyunsaturated fatty acids and particularly alpha-linolenic acid on the cerebral blood flow and on the tone of vessels that regulate brain perfusion. alpha-Linolenic acid injections increased cerebral blood flow and induced vasodilation of the basilar artery but not of the carotid artery. The saturated fatty acid palmitic acid did not produce vasodilation. This suggested that the target of the polyunsaturated fatty acids effect was the TREK-1 potassium channel. We demonstrate the presence of this channel in basilar but not in carotid arteries. We show that vasodilations induced by the polyunsaturated fatty acid in the basilar artery as well as the laser-Doppler flow increase are abolished in TREK-1(-/-) mice. Altogether these data indicate that TREK-1 activation elicits a robust dilation that probably accounts for the increase of cerebral blood flow induced by polyunsaturated fatty acids such as alpha-linolenic acid or docosahexanoic acid. They suggest that the selective expression and activation of TREK-1 in brain collaterals could play a significant role in the protective mechanisms of polyunsaturated fatty acids against stroke by providing residual circulation during ischemia. |
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Authors:
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Nicolas Blondeau; Olivier Pétrault; Stella Manta; Valérie Giordanengo; Pierre Gounon; Régis Bordet; Michel Lazdunski; Catherine Heurteaux |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-07 |
Journal Detail:
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Title: Circulation research Volume: 101 ISSN: 1524-4571 ISO Abbreviation: Circ. Res. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-20 Completed Date: 2007-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: United States |
Other Details:
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Languages: eng Pagination: 176-84 Citation Subset: IM |
Affiliation:
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Institut de Pharmacologie Moléculaire et Cellulaire, UMR 6097, CNRS Université de Nice Sophia Antipolis, Institut Paul Hamel, Valbonne, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects Brain Ischemia / metabolism*, pathology, physiopathology, prevention & control* Carotid Arteries / metabolism, pathology, physiopathology Cerebellum / blood supply, metabolism*, pathology, physiopathology Cerebrovascular Circulation / drug effects Gene Expression Regulation / drug effects* Laser-Doppler Flowmetry Mice Mice, Knockout Potassium Channels, Tandem Pore Domain / biosynthesis*, deficiency Rats Regional Blood Flow / drug effects Vasodilator Agents / pharmacology* alpha-Linolenic Acid / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels, Tandem Pore Domain; 0/Vasodilator Agents; 0/potassium channel protein TREK-1; 463-40-1/alpha-Linolenic Acid |
| Comments/Corrections | |
Comment In:
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Circ Res. 2007 Jul 20;101(2):119-21
[PMID:
17641234
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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