Document Detail

Polyunsaturated fatty acid status and neurodevelopment: a summary and critical analysis of the literature.
MedLine Citation:
PMID:  10102243     Owner:  NLM     Status:  MEDLINE    
The rationale for randomized trials designed to measure the effects of variable docosahexaenoic acid (DHA) status on neurodevelopment in human infants came from earlier studies of neurodevelopment in animals that were deficient in DHA owing to diets low in alpha-linolenic acid. The session on neurodevelopment looked at the results of these animal studies and discussed outcomes that appear to be analogous in human infants with variable DHA status. Presentations focused mainly on measures of development that may be attributed to more specific developmental domains (e.g., visual attention, recognition memory, problem-solving), some of which have been shown to be affected by long-chain polyunsaturated fatty acid (LCPUFA) status. This paper derives from discussions that took place during the session and reviews subsequent developments in this area. Although more difficult to interpret, global measures of infant development (e.g., the Bayley Scales of Infant Development, and Brunet-Lezine) can only suggest a relationship to specific developmental domains, but they have been applied in some randomized trials of LCPUFA and infant development. Those results are also summarized here.
S E Carlson; M Neuringer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lipids     Volume:  34     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-06-10     Completed Date:  1999-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  171-8     Citation Subset:  IM    
School of Nursing, The University of Missouri-Kansas City, USA.
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MeSH Terms
Docosahexaenoic Acids / administration & dosage*
Fatty Acids, Unsaturated / administration & dosage*
Models, Biological
Nervous System / growth & development*
Nervous System Physiological Phenomena
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids

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