Document Detail


Polyunsaturated Fatty Acid Plasma Content in Groups of General Population with lowvitamin B6 or low iron serum levels.
MedLine Citation:
PMID:  14988642     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experimental and human studies describe the adverse effect of iron or vitamin B6 deficiencies on polyunsaturated fatty acid metabolism. Iron is present in end proteins of the delta6-desaturase enzyme complex, and vitamin B6 deficiency can affect the transmethylation reaction of proteins. Plasma polyunsaturated fatty acid content was estimated in apparently healthy subjects of the general population with no consumption of fish and low vitamin B6 serum levels (< 3 microg/l; n = 21) or with low iron serum levels (men: < 12 micromol/l; women: < 10 micromol/l; n = 16) and compared to a control group (n = 22) with normal vitamin B6 and iron serum levels (in reference range). The activities of the delta6-desaturase enzyme complex were calculated as product/precursor (conversion indices). In groups of subjects with low vitamin B6 and low iron levels, delta6-desaturase activity together with delta5-desaturase activity (conversion of alpha-linolenic/18:3,n-3/ into eicosapentaenoic acid/20:5,n-3/) as well as the conversion index of docosahexaenoic acid formation (22:6,n-3) from 22:5,n-3 (second delta6-desaturase activity) were significantly reduced. The inhibition effect on fatty acid synthesis was more pronounced in subjects with low iron levels than in those with low vitamin B6 levels. The conversion indices correlated significantly positively with vitamin B6 or iron levels.
Authors:
M Krajcovicová-Kudlácková; J Klvanová; M Dusinská
Publication Detail:
Type:  Journal Article     Date:  2004-02-26
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  48     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2004  
Date Detail:
Created Date:  2004-04-16     Completed Date:  2004-08-26     Revised Date:  2010-10-06    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  118-21     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Affiliation:
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic. kudlackova@upkm.sk
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Fatty Acids, Unsaturated / blood,  metabolism*
Female
Humans
Iron / blood,  deficiency*
Male
Methylation
Middle Aged
Stearoyl-CoA Desaturase / metabolism*
Vitamin B 6 / blood
Vitamin B 6 Deficiency / blood*
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 7439-89-6/Iron; 8059-24-3/Vitamin B 6; EC 1.14.19.1/Stearoyl-CoA Desaturase; EC 1.14.19.3/FADS2 protein, human

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