| Polytherapy increases the risk of infertility in women with epilepsy. | |
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MedLine Citation:
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PMID: 20938026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Reproductive capability is an important concern for women with epilepsy (WWE). We aimed to ascertain the magnitude of infertility in a cohort of WWE who were anticipating pregnancy. METHODS: A prospective cohort of WWE enrolled in the Kerala Registry of Epilepsy and Pregnancy (1998-2007) in the preconception stage. The endpoint was occurrence of pregnancy. They were divided into those who remained infertile (IG group) and those who had become pregnant during the follow-up period (FG). RESULTS: Out of 375 women followed up for 1-10 years, 231 had pregnancy and 144 remained infertile (38.4%). Pregnancy occurred within 2 years of follow-up for most patients in the FG group. The IG group had higher mean age, lower education, and longer follow-up when compared to the FG group. Infertility was least (7.1%) for those with no antiepileptic drug (AED) exposure and higher (p = 0.001) with AED exposure (31.8% with 1 AED, 40.7% with 2 AED, and 60.3% with 3 or more AED exposure). Those exposed to phenobarbital had significant risk of infertility, but no such trend was observed with valproate or other drugs. On multiple logistic regression, use of 3 AEDs or more (odds ratio [OR] 17.9; 95% confidence interval [CI] 2.14-149.48), older age (OR 1.32; 95% CI 0.84-2.09), and low education (OR 2.91; 95% CI 1.82-4.65) remained as the important predictors of infertility. CONCLUSION: More than a third (38.4%) of WWE had infertility. The important predictors of infertility were exposure to multiple AEDs, older age, and lower education. |
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Authors:
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Sapna Cheravalloor Sukumaran; P Sankara Sarma; Sanjeev V Thomas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 75 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2010-10-29 Revised Date: 2011-06-03 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 1351-5 Citation Subset: AIM; IM |
Affiliation:
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Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anticonvulsants / adverse effects* Chi-Square Distribution Cohort Studies Drug Therapy, Combination / adverse effects* Epilepsy / drug therapy*, mortality Female Humans Infertility / chemically induced* Kaplan-Meier Estimate Pregnancy / drug effects* Retrospective Studies Risk Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
| Comments/Corrections | |
Comment In:
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Neurology. 2010 Oct 12;75(15):1316-7
[PMID:
20938024
]
Neurology. 2011 Apr 19;76(16):1442; author reply 1442 [PMID: 21502609 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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