Document Detail

Polysynaptic long-term potentiation: a physiological role of the perforant path--CA3/CA1 pyramidal cell synapse.
MedLine Citation:
PMID:  3416187     Owner:  NLM     Status:  MEDLINE    
Chronic stimulating and recording electrodes were implanted in the perforant path (PP), the dentate gyrus, and the CA3 and CA1 regions in adult rats. Input-output curves were constructed from PP-dentate, dentate-CA3, and CA3-CA1 responses before and after 9 high-frequency trains (400 Hz, 20 ms) delivered to PP. The stimulations produced enhancement of the population spikes at each pathway tested, lasting from 1 to 24 h. It is hypothesized that the potentiating effect in the test pathways (dentate-CA3, CA3-CA1) occurred as a result of coupling the tetanizing trains via the direct PP-CA3/CA1 synapses with the asynchronous polysynaptic volleys occurring in the intrahippocampal circuitry. The findings suggest that the physiological role of the direct PP-pyramidal cell synapse may be to enhance the effectiveness of other inputs to these neurons.
G Buzsàki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  455     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-10-14     Completed Date:  1988-10-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  192-5     Citation Subset:  IM    
Department of Physiology, University Medical School, Pècs, Hungary.
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MeSH Terms
Electric Stimulation
Hippocampus / anatomy & histology,  physiology*
Membrane Potentials
Neurons / physiology
Pyramidal Tracts / anatomy & histology,  physiology*
Synapses / physiology*

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