| Polysynaptic long-term potentiation: a physiological role of the perforant path--CA3/CA1 pyramidal cell synapse. | |
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MedLine Citation:
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PMID: 3416187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic stimulating and recording electrodes were implanted in the perforant path (PP), the dentate gyrus, and the CA3 and CA1 regions in adult rats. Input-output curves were constructed from PP-dentate, dentate-CA3, and CA3-CA1 responses before and after 9 high-frequency trains (400 Hz, 20 ms) delivered to PP. The stimulations produced enhancement of the population spikes at each pathway tested, lasting from 1 to 24 h. It is hypothesized that the potentiating effect in the test pathways (dentate-CA3, CA3-CA1) occurred as a result of coupling the tetanizing trains via the direct PP-CA3/CA1 synapses with the asynchronous polysynaptic volleys occurring in the intrahippocampal circuitry. The findings suggest that the physiological role of the direct PP-pyramidal cell synapse may be to enhance the effectiveness of other inputs to these neurons. |
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Authors:
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G Buzsàki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research Volume: 455 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1988-10-14 Completed Date: 1988-10-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 192-5 Citation Subset: IM |
Affiliation:
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Department of Physiology, University Medical School, Pècs, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Electric Stimulation Hippocampus / anatomy & histology, physiology* Male Membrane Potentials Neurons / physiology Pyramidal Tracts / anatomy & histology, physiology* Rats Synapses / physiology* |
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