Document Detail


Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms.
MedLine Citation:
PMID:  11704927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Strong genetic contributions to drug abuse vulnerability are well documented, but few chromosomal locations for human drug-abuse vulnerability alleles have been confirmed. We now identify chromosomal markers whose alleles distinguish drug abusers from control individuals in each of two samples, on the basis of pooled-sample microarray and association analyses. Reproducibly positive chromosomal regions defined by these markers in conjunction with previous results were especially unlikely to have been identified by chance. Positive markers identify the alcohol dehydrogenase (ADH) locus, flank the brain-derived neurotropic factor (BDNF) locus, and mark seven other regions previously linked to vulnerability to nicotine or alcohol abuse. These data support polygenic contributions of common allelic variants to polysubstance abuse vulnerability.
Authors:
G R Uhl; Q R Liu; D Walther; J Hess; D Naiman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2001-11-06
Journal Detail:
Title:  American journal of human genetics     Volume:  69     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2002-01-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1290-300     Citation Subset:  IM    
Affiliation:
Molecular Neurobiology Branch, National Institute of Drug Abuse, National Institutes of Health, Baltimore, MD, USA. guhl@intra.nida.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Africa / ethnology
African Continental Ancestry Group / genetics
Alcohol Dehydrogenase / genetics
Alcohol-Related Disorders / genetics
Alleles
Brain-Derived Neurotrophic Factor / genetics
Chromosome Mapping
Chromosomes, Human / genetics*
Europe / ethnology
European Continental Ancestry Group / genetics
Genetic Markers / genetics
Genetic Predisposition to Disease / genetics*
Humans
Multifactorial Inheritance / genetics
Nicotine / pharmacology
Polymorphism, Single Nucleotide / genetics*
Radiation Hybrid Mapping
Software
Substance-Related Disorders* / enzymology,  genetics*
United States
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Genetic Markers; 54-11-5/Nicotine; EC 1.1.1.1/Alcohol Dehydrogenase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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