Document Detail


Polyspecific malaria antibodies present at the time of infection inhibit the development of immunity to malaria but antibodies specific for the malaria merozoite surface protein, MSP1, facilitate immunity.
MedLine Citation:
PMID:  12060317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum taken from mice immune to malaria as a result of infection and drug cure, or from mice immunized with a recombinant form of the merozoite surface protein, MSP1, can provide passive protection of recipient mice against the lethal parasite, Plasmodium yoelii YM. However, recipients of MSP1-immune serum go on to develop long-term immunity, whereas recipients of serum from mice naturally immune to malaria rapidly lose their resistance to infection. We demonstrate that 'infection/cure' serum suppresses the development of both antibody and cell-mediated parasite-specific responses in recipients, whereas these develop in recipients of MSP1-specific antibodies. These data have profound implications for our understanding of the development of malaria immunity in babies who passively acquire antibodies from their mothers.
Authors:
Wenbao Zhang; Xue Qin Liu; Huji Xu; Michael F Good
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Parasite immunology     Volume:  24     ISSN:  0141-9838     ISO Abbreviation:  Parasite Immunol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-12     Completed Date:  2002-12-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  233-41     Citation Subset:  IM    
Affiliation:
The Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Protozoan* / biosynthesis*
Antibody Specificity*
Blotting, Western
Immune Sera / immunology
Immunity, Cellular
Immunization, Passive
Malaria / immunology*
Merozoite Surface Protein 1 / immunology*
Mice
Mice, Inbred BALB C
Plasmodium yoelii / immunology*
Protozoan Vaccines / immunology*
Time Factors
Vaccines, Synthetic / immunology
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan; 0/Immune Sera; 0/Merozoite Surface Protein 1; 0/Protozoan Vaccines; 0/Vaccines, Synthetic

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