| Polyspecific immunoglobulins (IVIg) suppress proliferation of human (auto)antigen-specific T cells without inducing apoptosis. | |
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MedLine Citation:
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PMID: 11240027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polyspecific immunoglobulins (IVIg) have been shown to reduce disease activity in multiple sclerosis (MS). To investigate the mechanisms of action of IVIg, we studied the impact of IVIg on growth and death (apoptosis) of human (auto)antigen-specific T cells. We observed a substantial suppression of proliferation of specifically activated T cells, in absence of caspase activation or DNA fragmentation. Further, neither susceptibility of T cells to undergo CD95-mediated apoptosis nor expression of apoptosis-blocking bcl-2 was modulated by IVIg. We conclude that IVIg may inhibit the reactivity of antigen-specific T cells in MS through suppression of proliferation rather than modulation of apoptosis. |
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Authors:
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O Aktas; S Waiczies; U Grieger; U Wendling; R Zschenderlein; F Zipp |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 114 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-12 Completed Date: 2001-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 160-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, Division of Neuroimmunology, University Hospital Charité, NWFZ 2680, Schumannstrasse 20/21, 10117 Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD95
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immunology Apoptosis / immunology* Autoantigens / immunology* Cell Division / immunology Cell Line Epitopes Humans Immunoglobulins, Intravenous / immunology*, pharmacology Multiple Sclerosis / immunology T-Lymphocytes / cytology*, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/Autoantigens; 0/Epitopes; 0/Immunoglobulins, Intravenous |
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