Document Detail

Polysialic acid enhances the migration and invasion of human cytotrophoblasts.
MedLine Citation:
PMID:  23208007     Owner:  NLM     Status:  MEDLINE    
Polysialic acid (polySia) is a large, cell-surface linear homopolymer composed of α2,8-linked sialic acid residues. Most extensively studied in the nervous system, this unique glycan modulates development by enhancing cell migration and regulating differentiation. PolySia also functions in developing and adult immune systems and is a signature of many cancers. In this study, we demonstrated that human placental trophoblasts, an epithelial lineage, also display this glycan. Cytotrophoblasts and syncytiotrophoblasts expressed polySia in the first trimester and downregulated it during the course of pregnancy. PolySia promoted cytotrophoblast migration in an explant model of chorionic villous growth. Removal of this glycan also reduced cytotrophoblast penetration of basement membranes in an in vitro model of invasion. Finally, we showed that polySia was overexpressed in biopsies from patients with gestational trophoblastic diseases, including benign molar pregnancies and malignant choriocarcinomas. These results demonstrated, for the first time, functional roles for polySia during normal human placental development and implicated these unusual oligosaccharides in the unrestrained invasion of trophoblast tumors.
Bethann S Hromatka; Penelope M Drake; Mirhan Kapidzic; Haley Stolp; Gabriel A Goldfien; Ie-Ming Shih; Susan J Fisher
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-12-03
Journal Detail:
Title:  Glycobiology     Volume:  23     ISSN:  1460-2423     ISO Abbreviation:  Glycobiology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-03-27     Completed Date:  2013-09-11     Revised Date:  2014-05-12    
Medline Journal Info:
Nlm Unique ID:  9104124     Medline TA:  Glycobiology     Country:  England    
Other Details:
Languages:  eng     Pagination:  593-602     Citation Subset:  IM    
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MeSH Terms
Cell Movement*
Choriocarcinoma / metabolism
Chorionic Villi / metabolism,  pathology
Hydatidiform Mole / metabolism
Neoplasm Invasiveness*
Sialic Acids / metabolism*
Trophoblasts / drug effects,  metabolism*
Tumor Cells, Cultured
Uterine Neoplasms / metabolism
Grant Support
1R21AI079329-01A1/AI/NIAID NIH HHS; P30 CA006973/CA/NCI NIH HHS
Reg. No./Substance:
0/Sialic Acids; 0/polysialic acid

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