Document Detail


Polysialic Acid Enhances the Migration and Invasion of Human Cytotrophoblasts.
MedLine Citation:
PMID:  23208007     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Polysialic acid is a large, cell-surface linear homopolymer composed of α2,8-linked sialic acid residues. Most extensively studied in the nervous system, this unique glycan modulates development by enhancing cell migration and regulating differentiation. PolySia also functions in the developing and adult immune systems and is a signature of many cancers. Here, we demonstrated that human placental trophoblasts, an epithelial lineage, also display this glycan. Cytotrophoblasts and syncytiotrophoblasts expressed polysialic acid in the first trimester and downregulated it during the course of pregnancy. Polysialic acid promoted cytotrophoblast migration in an explant model of chorionic villous growth. Removal of this glycan also reduced cytotrophoblast penetration of basement membranes in an in vitro model of invasion. Finally, we showed that polysialic acid was overexpressed in biopsies from patients with gestational trophoblastic diseases, including benign molar pregnancies and malignant choriocarcinomas. These results demonstrated, for the first time, functional roles for polysialic acid during normal human placental development and implicated these unusual oligosaccharides in the unrestrained invasion of trophoblast tumors.
Authors:
Bethann S Hromatka; Penelope M Drake; Mirhan Kapidzic; Haley Stolp; Gabriel A Goldfien; Ie-Ming Shih; Susan J Fisher
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  Glycobiology     Volume:  -     ISSN:  1460-2423     ISO Abbreviation:  Glycobiology     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104124     Medline TA:  Glycobiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA.
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