Document Detail


Polysaccharides with sulfate groups are human T cell mitogens and murine polyclonal B cell activators (PBAs) II. Cellulose sulfate and dextran sulfate with two different lower molecular weights.
MedLine Citation:
PMID:  6208459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In our previous paper, we reported that various types of carrageenan, dextran sulfate and fucoidan, which are sulfated homopolysaccharides with high molecular weights, were human T cell mitogens and murine polyclonal B cell activators (PBAs) and that heparin, a sulfated heteropolysaccharide, was a very weak human mitogen and mouse PBA. Here we used cellulose sulfate (Mr 7-9 X 10(3], dextran sulfate with two different low molecular weights (Mr 5 X 10(3) and 8 X 10(3], two different condroitin sulfates (Mr 3.5 X 10(4], polyvinyl sulfate and polygalacturonic acid to investigate mitogenic activities of polysaccharides in detail. The following results were obtained. Low-molecular-weight sulfated homopolysaccharides, dextran sulfate and cellulose sulfate, were very weak or not human T cell mitogens. However, they were better murine PBAs. Sulfated heteropolysaccharides, chondroitin 4-sulfate and chondroitin 6-sulfate, hardly induced mitogenic changes in human T cells and mouse B cells, even though the molecular weight of these substances was more than 1 X 10(4). There were no other polymers examined so far which activated both human T cells and murine B cells. The relationship among molecular size, sulfate groups and lymphocyte activation is discussed in detail.
Authors:
I Sugawara; S Ishizaka
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microbiology and immunology     Volume:  28     ISSN:  0385-5600     ISO Abbreviation:  Microbiol. Immunol.     Publication Date:  1984  
Date Detail:
Created Date:  1984-12-18     Completed Date:  1984-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703966     Medline TA:  Microbiol Immunol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  831-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
B-Lymphocytes / immunology
Cellulose / analogs & derivatives*,  pharmacology
Chondroitin Sulfates / pharmacology
Dextran Sulfate
Dextrans / pharmacology*
Female
Humans
Lymphocyte Activation / drug effects*
Male
Mice
Mitogens*
Molecular Weight
Pectins / pharmacology
Polysaccharides / pharmacology
Polyvinyls / pharmacology
T-Lymphocytes / immunology
Chemical
Reg. No./Substance:
0/Mitogens; 0/Pectins; 0/Polysaccharides; 0/Polyvinyls; 25191-25-7/polyvinyl sulfate; 9004-34-6/Cellulose; 9004-54-0/Dextrans; 9007-28-7/Chondroitin Sulfates; 9032-43-3/cellulose sulfate; 9042-14-2/Dextran Sulfate; 9046-38-2/polygalacturonic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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