| Polysaccharide from Gynura divaricata modulates the activities of intestinal disaccharidases in streptozotocin-induced diabetic rats. | |
| | |
MedLine Citation:
|
PMID: 21736823 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
During diabetes, structural and functional changes in the alimentary tract are known to take place resulting in an increased absorption of intestinal glucose and alterations in the activities of brush-border disaccharidases. To elucidate the effect of administrating polysaccharide from Gynura divaricata (PGD) on disaccharidase activities, the specific activities of intestinal disaccharidases, namely sucrase, maltase and lactase, were measured in streptozotocin-induced diabetic rats. Normal control and diabetic rats were treated by oral administration with PGD. Specific activities of intestinal disaccharidases were increased significantly during diabetes, and amelioration of the activities of sucrase and maltase during diabetes was clearly visible by the treatment with PGD. However, the increased activity of lactase during diabetes mellitus was remarkably alleviated by the administration of PGD only in the duodenum. Meanwhile, oral sucrose tolerance tests demonstrated that PGD alleviated the hyperglycaemia during diabetes mellitus, resulting from the amelioration in the activities of intestinal disaccharidases. The present investigation suggests that PGD exerted an anti-diabetic effect partly via inhibiting the increased intestinal disaccharidase activities of diabetic rats. This beneficial influence of administration of PGD on intestinal disaccharidases clearly indicates their helpful role in the management of diabetes. |
| | |
Authors:
|
Yuan-Xiong Deng; Yu-Shuang Chen; Wei-Ran Zhang; Bo Chen; Xi-Min Qiu; Li-Hua He; Ling-Li Mu; Chang-Hua Yang; Rong Chen |
Related Documents
:
|
22556603 - Anti diabetic activity of amrithadi churnam. 15052533 - A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropath... 11574403 - Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-31 |
Journal Detail:
|
Title: The British journal of nutrition Volume: - ISSN: 1475-2662 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-7-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: 1-7 Citation Subset: - |
Affiliation:
|
Department of Pharmaceutical Science, Medical College of Hunan Normal University, Changsha 410013, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nutrient-based standards for school lunches complement food-based standards and improve pupils' nutr...
Next Document: Ethnic differences in the relationship between body mass index and percentage body fat among Asian c...