Document Detail

Polysaccharide extract isolated from ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury.
MedLine Citation:
PMID:  15215656     Owner:  NLM     Status:  MEDLINE    
The effect of polysaccharide extract isolated from Ganoderma lucidum (Gl-PS) on rat cortical neuronal cultures exposed to hypoxia/reoxygenation (H/R) was studied in vitro. Gl-PS (1, 10, 100 microg/ml) increased neuron viability following H/R as measured by the inhibition of MTT reduction. Gl-PS also significantly reduced malondialdehyde content and reactive oxygen species production and increased the manganese superoxide dismutase (Mn-SOD) activity; furthermore, the translocation of nuclear factor-kappa B induced by H/R was blocked. These findings suggest that Gl-PS might be useful in treating H/R-induced oxidative stress and Mn-SOD might play a critical role in the neuroprotective effect of Gl-PS against H/R injury.
Hong-Bo Zhao; Shu-Qian Lin; Ji-Hong Liu; Zhi-Bin Lin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacological sciences     Volume:  95     ISSN:  1347-8613     ISO Abbreviation:  J. Pharmacol. Sci.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-24     Completed Date:  2005-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167001     Medline TA:  J Pharmacol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  294-8     Citation Subset:  IM    
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
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MeSH Terms
Cell Survival / drug effects
Cells, Cultured
Cerebral Cortex / drug effects,  pathology*
Fluorescent Antibody Technique
Hypoxia, Brain / pathology*,  prevention & control*
Malondialdehyde / metabolism
Microscopy, Confocal
NF-kappa B
Neuroprotective Agents*
Oxidative Stress / drug effects
Oxygen / pharmacology
Polysaccharides / isolation & purification,  pharmacology*
Rats, Sprague-Dawley
Reishi / chemistry*
Superoxide Dismutase / metabolism
Tetrazolium Salts
Reg. No./Substance:
0/NF-kappa B; 0/Neuroprotective Agents; 0/Polysaccharides; 0/Tetrazolium Salts; 0/Thiazoles; 298-93-1/thiazolyl blue; 542-78-9/Malondialdehyde; 7782-44-7/Oxygen; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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