Document Detail


Polypyrrole nanowire modified with Gly-Gly-His tripeptide for electrochemical detection of copper ion.
MedLine Citation:
PMID:  20630738     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
We developed a novel biosensor comprising a transducer of carboxyl end-capped overoxidized polypyrrole nanowire electrode and a probe of tripeptide (Gly-Gly-His) selectively cognitive of Cu2+. The developed sensor was demonstrated to specifically detect Cu2+ in the nanomolar range. The diameter of the polypyrrole nanowires, prepared by one step template-free polymerization, was approximately 60-90 nm. For functionalization of the electrode, the carboxyl group was introduced by the addition of pyrrole-α-carboxylic acid which was covalently coupled with the amine group of the tripeptide. The structural features of the peptide functionalized nanowire electrode were confirmed by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) spectroscopy. Using cyclic and square wave voltammetry, the nanowire biosensor proved to be highly sensitive to Cu2+ in the range of 20-300 nM.
Authors:
Meng Lin; Misuk Cho; Woo-Seok Choe; Ji-Beom Yoo; Youngkwan Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-25
Journal Detail:
Title:  Biosensors & bioelectronics     Volume:  26     ISSN:  1873-4235     ISO Abbreviation:  Biosens Bioelectron     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001289     Medline TA:  Biosens Bioelectron     Country:  England    
Other Details:
Languages:  eng     Pagination:  940-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Chemical Engineering. Sungkyunkwan University, Suwon 440-746, Republic of Korea.
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