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Polypyrrole-contained electrospun conductive nanofibrous membranes for cardiac tissue engineering.
MedLine Citation:
PMID:  22021185     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cardiac tissue engineering (TE) is one of the most promising strategies to reconstruct infarct myocardium and the major challenge is to generate a bioactive substrate with suitable chemical, biological, and conductive properties, thus mimicking the extracellular matrix (ECM) both structurally and functionally. In this study, polypyrrole/poly(ε-caprolactone)/gelatin nanofibrous scaffolds were electrospun by incorporating different concentrations of polypyrrole (PPy) to PCL/gelatin (PG) solution. Morphological, chemical, mechanical, and biodegradation properties of the electrospun nanofibers were evaluated. Our data indicated that by increasing the concentration of PPy (0-30%) in the composite, the average fiber diameters reduced from 239 ± 37 nm to 191 ± 45 nm, and the tensile modulus increased from 7.9 ± 1.6 MPa to 50.3 ± 3.3 MPa. Conductive nanofibers containing 15% PPy (PPG15) exhibited the most balanced properties of conductivity, mechanical properties, and biodegradability, matching the requirements for regeneration of cardiac tissue. The cell proliferation assay, SEM, and immunostaining analysis showed that the PPG15 scaffold promote cell attachment, proliferation, interaction, and expression of cardiac-specific proteins better than PPG30. Electrospun PPG15 conductive nanofibrous scaffold could be desirable and promising substrates suitable for the regeneration of infarct myocardium and cardiac defects. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
Authors:
Dan Kai; Molamma P Prabhakaran; Guorui Jin; Seeram Ramakrishna
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Publication Detail:
Type:  Journal Article     Date:  2011-08-23
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  99     ISSN:  1552-4965     ISO Abbreviation:  J Biomed Mater Res A     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  376-85     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Affiliation:
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.
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