Document Detail

Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity.
MedLine Citation:
PMID:  22215808     Owner:  NLM     Status:  MEDLINE    
Proper development requires coordination in growth of the cell types composing an organ. Many plant and animal cells are polyploid, but how these polyploid tissues contribute to organ growth is not well understood. We found the Drosophila melanogaster subperineurial glia (SPG) to be polyploid, and ploidy is coordinated with brain mass. Inhibition of SPG polyploidy caused rupture of the septate junctions necessary for the blood-brain barrier. Thus, the increased SPG cell size resulting from polyploidization is required to maintain the SPG envelope surrounding the growing brain. Polyploidization likely is a conserved strategy to coordinate tissue growth during organogenesis, with potential vertebrate examples.
Yingdee Unhavaithaya; Terry L Orr-Weaver
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes & development     Volume:  26     ISSN:  1549-5477     ISO Abbreviation:  Genes Dev.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-04     Completed Date:  2012-02-13     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Whitehead Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
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MeSH Terms
Blood-Brain Barrier / cytology,  growth & development
Cell Size
Drosophila melanogaster / cytology*,  genetics*,  growth & development
Nervous System / growth & development
Neuroglia / cytology
Neurons / cytology

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