| Polyplex gene delivery modulated by redox potential gradients. | |
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MedLine Citation:
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PMID: 17050118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polyplexes sensitive to redox potential gradients represent a promising class of vectors for delivery of nucleic acids. This review focuses on the recent advances in the development of these vectors. The biological rationale for the design of redox-sensitive polyplexes is discussed together with the basic synthetic approaches for introducing reducible disulfide bonds into the structure of the polyplexes. The biological properties of the redox-sensitive polyplexes of plasmid DNA, mRNA, antisense oligonucleotides and siRNA are reviewed with emphasis on in vitro cellular delivery, cytotoxicity and in vivo activity. Overall, redox-sensitive polyplexes represent a promising platform for further development as vectors for delivery of a wide variety of therapeutic nucleic acids. |
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Authors:
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Devika Soundara Manickam; David Oupický |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Journal of drug targeting Volume: 14 ISSN: 1061-186X ISO Abbreviation: J Drug Target Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-10-19 Completed Date: 2008-06-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312476 Medline TA: J Drug Target Country: England |
Other Details:
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Languages: eng Pagination: 519-26 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48202, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA / administration & dosage* Gene Transfer Techniques* Genetic Vectors / chemistry* Humans Oligonucleotides, Antisense / administration & dosage Oxidation-Reduction Plasmids / administration & dosage Polyamines / chemistry RNA, Messenger / administration & dosage RNA, Small Interfering / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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CA109711/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Oligonucleotides, Antisense; 0/Polyamines; 0/RNA, Messenger; 0/RNA, Small Interfering; 0/polycations; 9007-49-2/DNA |
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