Document Detail

Polypill: the evidence and the promise.
MedLine Citation:
PMID:  19884824     Owner:  NLM     Status:  In-Process    
PURPOSE OF REVIEW: In spite of great scientific advances, cardiovascular disease is the commonest cause of death worldwide and current cardiovascular prevention strategies fail to achieve the full potential of risk modification. A large amount of evidence supports the use of pharmacological treatments both in primary and secondary prevention and it was hypothesized that a fixed-dose combination of such drugs, a 'polypill', may greatly simplify and improve current prevention strategies. RECENT FINDINGS: Several polypill formulations have been developed and a recent trial demonstrated the short-term feasibility, safety and efficacy (in reducing risk factor levels) of a polypill in individuals at moderate risk. Many challenges remain and studies are underway, which will address questions related to formulation of polypill(s), the long-term safety and tolerability, the efficacy in reducing risk factor levels and cardiovascular events, physician, patient and societal acceptability, adherence, regulatory requirements, cost and impact on lifestyle habits. SUMMARY: Theoretical models suggest that a polypill containing low-dose aspirin, three blood pressure-lowering drugs at half dose and a potent statin, administered to a large proportion of the population at risk for cardiovascular events, could reduce ischemic heart disease and strokes by over 80%. The feasibility of this approach has recently been shown in a clinical trial and ongoing studies will define whether the postulated benefits of the polypill will be observed.
Eva Lonn; Salim Yusuf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in lipidology     Volume:  20     ISSN:  1473-6535     ISO Abbreviation:  Curr. Opin. Lipidol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010000     Medline TA:  Curr Opin Lipidol     Country:  England    
Other Details:
Languages:  eng     Pagination:  453-9     Citation Subset:  IM    
Population Health Research Institute and Department of Medicine, Division of Cardiology, McMaster University, Hamilton, Ontario, Canada.
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