Document Detail

Polyphosphate and stress response in mycobacteria.
MedLine Citation:
PMID:  17590232     Owner:  NLM     Status:  MEDLINE    
Polyphosphate (poly P) is present in every living cell. Long considered a 'molecular fossil', its role in cell physiology has been neglected. However, in the last few years it has become clear that poly P plays a role in multiple physiological functions, the best characterized of which is rpoS and recA induction during the Escherichia coli stringent response. Sureka et al. in this issue of Molecular Microbiology investigate the role of poly P in mycobacterial stress response and describe its participation in a novel regulatory pathway involving the two-component system MprAB, the alternative sigma factor sigma(E) and Rel, the enzyme responsible for (p)ppGpp metabolism in mycobacteria.
Riccardo Manganelli
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-21
Journal Detail:
Title:  Molecular microbiology     Volume:  65     ISSN:  0950-382X     ISO Abbreviation:  Mol. Microbiol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-16     Completed Date:  2007-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712028     Medline TA:  Mol Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  258-60     Citation Subset:  IM    
Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy.
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MeSH Terms
Mycobacterium / physiology*
Polyphosphates / metabolism*
Reg. No./Substance:

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