| Polyphenols prevent lipid abnormalities and arterial dysfunction in hamsters on a high-fat diet: a comparative study of red grape and white persimmon wines. | |
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MedLine Citation:
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PMID: 21879099 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Scope: We compared the effects of two dealcoholized wines, persimmon (P) and Merlot (M), in hypercholesterolemic hamsters. Methods and results: Four groups of hamsters received a standard (ST) or an atherogenic diet (AT) for 12 weeks. AT animals received either dealcoholized persimmon wine (AT + P) or Merlot wine (AT + M) by gavage, while controls received water (AT and ST). Plasma cholesterol, triglycerides and glucose and paraoxonase activity were measured. Oxidative stress was assessed by aortic O(2)°(-) production, and vascular function was evaluated in aortic rings. The atherogenic diet led to higher plasma triglycerides (246%), total cholesterol (142%), LDL-cholesterol (91%) and HDL-cholesterol (49%). Aortic production of O(2)°(-) also increased (207%) and vascular reactivity was modified with altered endothelial function as assessed by acetylcholine-dependent vasorelaxation. The two wines partially prevented these alterations, reducing O(2)°(-) production and improving vascular reactivity without altering endothelial function. There was no difference between the P and M groups, although the procyanidin composition of the two dealcoholized fractions differed significantly, and only dimer concentrations were similar. Conclusion: These findings indicate that polyphenols are responsible, at least in part, for the antiatherogenic/antioxidant effects of wines. |
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Authors:
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Jin-Hyang Suh; Anne Virsolvy; Aurélie Goux; Cécile Cassan; Sylvain Richard; Jean-Paul Cristol; Pierre-Louis Teissèdre; Jean-Max Rouanet |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-30 |
Journal Detail:
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Title: Food & function Volume: - ISSN: 2042-650X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101549033 Medline TA: Food Funct Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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UMR 204-Prévention des Malnutritions et des Pathologies Associées, Université Montpellier 1 & 2, Place E. Bataillon, CC 023, 34095 Montpellier cedex 5, France. jm.rouanet@univ-montp2.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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