| Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells. | |
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MedLine Citation:
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PMID: 20511673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study offers a new look at the role of erythrocytes and of erythrocytes-polyphenol complexes as potent 'sinks' for reactive oxygen species. We hereby show that human erythrocytes have the capacity not only to carry oxygen, but also to bind avidly to their surfaces a large variety of polyphenol antioxidants, which endows upon such complexes enhanced total oxidant-scavenging capacities (TOSC). This was proven by using confocal microscopy, 2,2-diphenyl-1-picrylhydrazyl radical, Folin-Ciocalteu's reagent, cyclic voltammetry and chemiluminescence techniques. The results presented suggest that the true TOSC of blood is the sum of intracellular antioxidants of red blood cells and other blood cells (mainly due to catalase), the polyphenols bound to their surfaces and the antioxidant agents present in plasma. Since erythrocytes can avidly bind and rapidly remove circulating polyphenols, the rule of the thumb to quantify antioxidants in health and disease processes exclusively in plasma as customary in clinical settings, does not represent the true TOSC of whole blood. We also postulate that circulating erythrocytes and possibly also other blood cells might be constantly coated by polyphenols from supplemented nutrients, which act as antioxidant depots and can thus act as protectors against the harmful consequences of oxidative stress. Further studies are needed to determine the faith of polyphenols in the circulation and their sequestration in the spleen. |
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Authors:
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Erez Koren; Ron Kohen; Isaac Ginsburg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental biology and medicine (Maywood, N.J.) Volume: 235 ISSN: 1535-3699 ISO Abbreviation: Exp. Biol. Med. (Maywood) Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-06-15 Revised Date: 2010-07-29 |
Medline Journal Info:
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Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: England |
Other Details:
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Languages: eng Pagination: 689-99 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, School of Pharmacy, Hadassah Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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metabolism,
pharmacology* Erythrocytes / chemistry, metabolism, physiology* Flavonoids / metabolism, pharmacology* Free Radical Scavengers / metabolism, pharmacology* Humans Oxidants / antagonists & inhibitors* Phenols / metabolism, pharmacology* Reactive Oxygen Species / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Flavonoids; 0/Free Radical Scavengers; 0/Oxidants; 0/Phenols; 0/Reactive Oxygen Species; 0/polyphenols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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