Document Detail


Polyphenolics and fat absorption.
MedLine Citation:
PMID:  14970839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To elucidate whether the acute consumption of red wine polyphenolic compounds regulates lipid and lipoprotein metabolism in dyslipidemic postmenopausal women. DESIGN: Eight dyslipidemic postmenopausal women each consumed a mixed meal accompanied by either water, dealcoholized red wine or alcoholic red wine on three separate visits, in a random order, 2 weeks apart. One fasting and six hourly postmeal blood samples were taken and analyzed for plasma apolipoprotein B48 (apoB48; specific marker of chylomicrons (CM) and their remnants (CMR)); total-, LDL- and HDL-cholesterol; triglycerides (TAG); insulin and glucose at each time point. RESULTS: There was a decrease in postprandial apoB48 levels after alcoholic and nonalcoholic red wine consumption compared to water. CONCLUSION: Red wine attenuates postprandial CM and CMR levels in plasma, possibly by delaying the absorption of dietary fat, as suggested by a decrease in plasma apoB48 levels. The reduction of postprandial lipoproteins in circulation after red wine consumption may partly explain the low cardiovascular mortality rates among the French.
Authors:
S Pal; M Naissides; J Mamo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  28     ISSN:  0307-0565     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-18     Completed Date:  2004-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  324-6     Citation Subset:  IM    
Affiliation:
Department of Nutrition, Dietetics and Food Sciences, Curtin University, Perth Western Australia, Australia. s.pal@curtin.edu.au
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MeSH Terms
Descriptor/Qualifier:
Apolipoprotein B-48
Apolipoproteins B / blood
Female
Flavonoids / pharmacology*
Humans
Hyperlipidemias / blood*
Intestinal Absorption / drug effects
Lipids / blood*
Phenols / pharmacology*
Postmenopause / blood
Postprandial Period / physiology
Wine / analysis*
Chemical
Reg. No./Substance:
0/Apolipoprotein B-48; 0/Apolipoproteins B; 0/Flavonoids; 0/Lipids; 0/Phenols; 0/polyphenols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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