Document Detail

Polyphenol-rich beverages enhance zinc uptake and metallothionein expression in Caco-2 cells.
MedLine Citation:
PMID:  20546406     Owner:  NLM     Status:  MEDLINE    
The effect of red wine (RW), red grape juice (RGJ), green tea (GT), and representative polyphenols on Caco-2 cell (65)Zn uptake was explored. RW, RGJ, and GT enhanced the uptake of zinc from rice matrix. Fractionation of RW revealed that enhancing activity of zinc uptake was exclusively resided in the polyphenol fraction. Among the polyphenols tested, only tannic acid and quercitin stimulated the uptake of zinc while others did not influence the uptake. In tune with these results, only tannic acid and quercitin competed with zinquin (a zinc selective fluorophore) for zinc in vitro. Although all the polyphenols tested appear to enhance the expression of metallothionein (MT), the induction was higher with tannic acid, quercitin, and RW extract. Furthermore, phytic acid abrogated the tannic acid-induced MT expression. These results suggest that polyphenol-rich beverages, tannic acid, and quercitin bind and stimulate the zinc uptake and MT expression in Caco-2 cells.
Kilari Sreenivasulu; Pullakhandam Raghu; K Madhavan Nair
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of food science     Volume:  75     ISSN:  1750-3841     ISO Abbreviation:  J. Food Sci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-15     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H123-8     Citation Subset:  IM    
Micronutrient Research Group, Biophysics Div., Natl. Inst. of Nutrition (Indian Council of Medical Research), Jamai Osmania, Hyderabad 500 604, India.
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MeSH Terms
Absorption / drug effects*
Beverages / analysis*
Binding, Competitive
Caco-2 Cells
Chelating Agents / chemistry
Flavonoids / analysis*,  chemistry,  isolation & purification,  pharmacology*
Fruit / chemistry
Metallothionein / metabolism*
Oryza sativa / chemistry,  metabolism
Phenols / analysis*,  chemistry,  isolation & purification,  pharmacology*
Phytic Acid / analysis,  pharmacology
Quercetin / chemistry,  pharmacology
Quinolones / chemistry
Seeds / chemistry,  metabolism
Tannins / analysis,  antagonists & inhibitors,  chemistry,  pharmacology
Tea / chemistry
Tosyl Compounds / chemistry
Up-Regulation / drug effects*
Vitis / chemistry
Wine / analysis
Zinc / analysis,  chemistry,  pharmacokinetics*
Zinc Radioisotopes / pharmacokinetics
Reg. No./Substance:
0/Chelating Agents; 0/Flavonoids; 0/Phenols; 0/Quinolones; 0/Tannins; 0/Tea; 0/Tosyl Compounds; 0/Zinc Radioisotopes; 0/polyphenols; 117-39-5/Quercetin; 151606-29-0/zinquin; 7440-66-6/Zinc; 83-86-3/Phytic Acid; 9038-94-2/Metallothionein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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