| Polyphenol-rich beverages enhance zinc uptake and metallothionein expression in Caco-2 cells. | |
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MedLine Citation:
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PMID: 20546406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of red wine (RW), red grape juice (RGJ), green tea (GT), and representative polyphenols on Caco-2 cell (65)Zn uptake was explored. RW, RGJ, and GT enhanced the uptake of zinc from rice matrix. Fractionation of RW revealed that enhancing activity of zinc uptake was exclusively resided in the polyphenol fraction. Among the polyphenols tested, only tannic acid and quercitin stimulated the uptake of zinc while others did not influence the uptake. In tune with these results, only tannic acid and quercitin competed with zinquin (a zinc selective fluorophore) for zinc in vitro. Although all the polyphenols tested appear to enhance the expression of metallothionein (MT), the induction was higher with tannic acid, quercitin, and RW extract. Furthermore, phytic acid abrogated the tannic acid-induced MT expression. These results suggest that polyphenol-rich beverages, tannic acid, and quercitin bind and stimulate the zinc uptake and MT expression in Caco-2 cells. |
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Authors:
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Kilari Sreenivasulu; Pullakhandam Raghu; K Madhavan Nair |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of food science Volume: 75 ISSN: 1750-3841 ISO Abbreviation: J. Food Sci. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-15 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0014052 Medline TA: J Food Sci Country: United States |
Other Details:
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Languages: eng Pagination: H123-8 Citation Subset: IM |
Affiliation:
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Micronutrient Research Group, Biophysics Div., Natl. Inst. of Nutrition (Indian Council of Medical Research), Jamai Osmania, Hyderabad 500 604, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorption
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drug effects* Beverages / analysis* Binding, Competitive Caco-2 Cells Chelating Agents / chemistry Digestion Flavonoids / analysis*, chemistry, isolation & purification, pharmacology* Fruit / chemistry Humans Metallothionein / metabolism* Oryza sativa / chemistry, metabolism Phenols / analysis*, chemistry, isolation & purification, pharmacology* Phytic Acid / analysis, pharmacology Quercetin / chemistry, pharmacology Quinolones / chemistry Seeds / chemistry, metabolism Tannins / analysis, antagonists & inhibitors, chemistry, pharmacology Tea / chemistry Tosyl Compounds / chemistry Up-Regulation / drug effects* Vitis / chemistry Wine / analysis Zinc / analysis, chemistry, pharmacokinetics* Zinc Radioisotopes / pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 0/Flavonoids; 0/Phenols; 0/Quinolones; 0/Tannins; 0/Tea; 0/Tosyl Compounds; 0/Zinc Radioisotopes; 0/polyphenols; 117-39-5/Quercetin; 151606-29-0/zinquin; 7440-66-6/Zinc; 83-86-3/Phytic Acid; 9038-94-2/Metallothionein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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