Document Detail


Polyphenol-enriched apple extract attenuates food allergy in mice.
MedLine Citation:
PMID:  20175787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The immune system may be modulated with nutrition to prevent the development or to treat the symptoms of allergy. Among other foods, consumption of apples has been linked to reduced incidence of atopic dermatitis and respiratory allergy. OBJECTIVE: We evaluated the efficacy and mechanisms of a polyphenol-enriched apple extract in reducing symptoms of food allergy. METHODS: In a model of food allergy to ovalbumin (OVA), BALB/c mice were fed with an apple extract either during sensitization or just before the challenge. After the challenge, allergic symptoms were scored, OVA-specific serum immunoglobulins were determined by ELISA, cytokine production by mesenteric lymph node (MLN) cells was measured by a multiplex assay and gene expression profiles in the intestine were addressed using quantitative real-time PCR. RESULTS: Consumption of the apple extract reduced symptoms of food allergy upon challenge. This was paralleled by reduced levels of intestinal mast cell protease, diminished cytokine secretion by MLN cells and reduced local intestinal mRNA expression of various T-helper type-2 associated and pro-inflammatory genes. Mechanistic studies suggested decrease of mediator release by effector cells and reduction of allergenicity by protein-polyphenol interaction as potential mechanisms responsible for protection. CONCLUSION: Polyphenol-enriched apple extract can attenuate food allergy symptoms in sensitized mice via two distinct possible mechanisms.
Authors:
A W Zuercher; S Holvoet; M Weiss; A Mercenier
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Publication Detail:
Type:  Journal Article     Date:  2010-02-17
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  40     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  942-50     Citation Subset:  IM    
Affiliation:
Allergy Group, Department of Nutrition and Health, Nestle Research Center, Lausanne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chlorogenic Acid / administration & dosage,  therapeutic use*
Cytokines / metabolism
Disease Models, Animal
Flavonoids / administration & dosage,  therapeutic use*
Food Hypersensitivity / drug therapy*,  immunology
Gene Expression Profiling
Hypersensitivity, Immediate / drug therapy*,  immunology
Immunoglobulins / blood
Intestines / metabolism
Mice
Mice, Inbred BALB C
Ovalbumin / immunology
Plant Extracts / administration & dosage,  therapeutic use*
Tannins / administration & dosage,  therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cytokines; 0/Flavonoids; 0/Immunoglobulins; 0/Plant Extracts; 0/Tannins; 0/apple polyphenol extract; 327-97-9/Chlorogenic Acid; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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