Document Detail

Polyphenol-induced endothelium-dependent relaxations role of NO and EDHF.
MedLine Citation:
PMID:  21081218     Owner:  NLM     Status:  In-Process    
The Mediterranean diet has been associated with greater longevity and quality of life in epidemiological studies. Indeed, because of the abundance of fruits and vegetables and a moderate consumption of wine, the Mediterranean diet provides high amounts of polyphenols thought to be essential bioactive compounds that might provide health benefits in terms of cardiovascular diseases and mortality. Several polyphenol-rich sources, such as grape-derived products, cocoa, and tea, have been shown to decrease mean blood pressure in patients with hypertension. The improvement of the endothelial function is likely to be one of the mechanisms by which polyphenols may confer cardiovascular protection. Indeed, polyphenols are able to induce nitric oxide (NO)-mediated endothelium-dependent relaxations in a large number of arteries including the coronary artery; they can also induce endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxations in some of these arteries. Altogether, these mechanisms might contribute to explain the antihypertensive and cardio-protective effects of polyphenols in vivo. The aim of this review was to provide a nonexhaustive analysis of the effect of several polyphenol-rich sources and isolated compounds on the endothelium in in vitro, ex vivo, and in vivo models as well as in humans.
Valérie B Schini-Kerth; Cyril Auger; Nelly Etienne-Selloum; Thierry Chataigneau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in pharmacology (San Diego, Calif.)     Volume:  60     ISSN:  1557-8925     ISO Abbreviation:  Adv. Pharmacol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9015397     Medline TA:  Adv Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-75     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Laboratoire de Biophotonique et Pharmacologie, UMR 7213 CNRS, Université de Strasbourg, Faculté de Pharmacie, Illkirch, France.
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