| Polypharmacy and potentially inappropriate medication use among community-dwelling elders with dementia. | |
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MedLine Citation:
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PMID: 19561441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This cross-sectional study examines the association between total prescription medication use and potentially inappropriate medication use (PIRx) among community-dwelling elderly patients with and without dementia. Data (September 2005 to September 2007) were from the National Institute on Aging-funded National Alzheimer's Coordinating Center Uniform Data Set. The study analyzed the Uniform Data Set initial visits of 4518 community-dwelling subjects aged 65 years and above with and without dementia (2665 and 1853, respectively). PIRx was defined using a partial list of the 2003 Beers criteria. Generalized linear mixed models were applied to estimate the association between PIRx and polypharmacy. In both groups (with and without dementia), subjects who received PIRx on average took more medications than those taking no PIRx. As the total number of medications used increased, the odds of having PIRx also increased, controlling for dementia diagnosis and other subject characteristics. Our key findings were consistent after considering 2 definitions of PIRx (with or without oral estrogens) and accounting for missing data. In summary, the total number of medications used is associated with PIRx among Alzheimer's Disease Centers community-dwelling elderly patients with and without dementia, with polypharmacy increasing the risk of PIRx. Ensuring appropriate medication use in this population is clinically important because of the significant risks for institutionalization. |
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Authors:
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Denys T Lau; Nathaniel D Mercaldo; Andrew T Harris; Emily Trittschuh; Joseph Shega; Sandra Weintraub |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Alzheimer disease and associated disorders Volume: 24 ISSN: 1546-4156 ISO Abbreviation: Alzheimer Dis Assoc Disord Publication Date: 2010 Jan-Mar |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-06-17 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8704771 Medline TA: Alzheimer Dis Assoc Disord Country: United States |
Other Details:
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Languages: eng Pagination: 56-63 Citation Subset: IM |
Affiliation:
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Buehler Center on Aging, Health & Society, Northwestern University, Chicago, IL, USA. d-lau@northwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Cross-Sectional Studies Dementia / drug therapy* Drug Utilization / statistics & numerical data* Humans Polypharmacy* Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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1-T32AG20506-01-05/AG/NIA NIH HHS; 5K01AG027295-02/AG/NIA NIH HHS; AG13854/AG/NIA NIH HHS; K01 AG027295-02/AG/NIA NIH HHS; P30 AG013854-13/AG/NIA NIH HHS; T32 AG020506-07/AG/NIA NIH HHS; U01 AG016976-09/AG/NIA NIH HHS; U01AG016976/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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