Document Detail

Polypeptides and 100 years of chemistry of alpha-amino acid N-carboxyanhydrides.
MedLine Citation:
PMID:  16948174     Owner:  NLM     Status:  MEDLINE    
Syntheses and polymerizations of alpha-amino acid N-carboxyanhydrides (NCAs) were reported for the first time by Hermann Leuchs in 1906. Since that time, these cyclic and highly reactive amino acid derivatives were used for stepwise peptide syntheses but mainly for the formation of polypeptides by ring-opening polymerizations. This review summarizes the literature after 1985 and reports on new aspects of the polymerization processes, such as the formation of cyclic polypeptides or novel organometal catalysts. Polypeptides with various architectures, such as diblock, triblock, and multiblock sequences, and star-shaped or dendritic structures are also mentioned. Furthermore, lyotropic and thermotropic liquid-crystalline polypeptides will be discussed and the role of polypeptides as drugs or drug carriers are reviewed. Finally, the hypothetical role of NCAs in molecular evolution on the prebiotic Earth is discussed.
Hans R Kricheldorf
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  45     ISSN:  1433-7851     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-07     Completed Date:  2006-10-25     Revised Date:  2007-01-19    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  5752-84     Citation Subset:  IM    
Institut für Technische und Makromolekulare Chemie, Universität Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany.
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MeSH Terms
Anhydrides / chemistry*
Peptides / chemistry*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Reg. No./Substance:
0/Anhydrides; 0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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