| Polypeptide modulators of card-card-mediated protein-protein interactions. | |
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MedLine Citation:
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PMID: 22065589 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The CARD (caspase recruitment domain) domain is present in a large number of proteins. Initially the CARD domain was recognized as part of the caspase activation machinery. CARD-CARD interactions play a role in apoptosis and are responsible for the Apaf-1 mediated activation of procaspase-9 in the apoptosome. CARD-containing proteins mediate the inflammasome-dependent activation of pro-inflammatory caspase-1. More recently new roles for CARD-containing proteins have been reported in signaling pathways associated with immune responses. The functional role of CARD-containing proteins and CARD domains in coordinating apoptosis, inflammatory and immune responses is not completely understood. We have explored the putative crosstalk between apoptosis and inflammation by analyzing the modulatory activity on both the Apaf-1/procaspase-9 interaction and the inflammasome-mediated procaspase-1 activation of CARD-derived polypeptides. To this end we analyzed the activity of individual recombinant CARD domains, rational designed CARD-derived peptides and peptides derived from phage display. |
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Authors:
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Yadira Palacios-Rodriguez; Guillermo Garcia-Lainez; Monica Sancho; Anna Gortat; Mar Orzaez; Enrique Perez-Paya |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: - ISSN: 1083-351X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centro de Investigacion Principe Felipe, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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