Document Detail

Polyp volume versus linear size measurements at CT colonography: implications for noninvasive surveillance of unresected colorectal lesions.
MedLine Citation:
PMID:  16714649     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Proposed surveillance of unresected medium-sized (6.0-9.9 mm) polyps will require reliable detection of small incremental changes. The purpose of this study was to assess the reproducibility of linear versus volume measurements of polyp size at CT colonography (CTC) and to correlate results with a hemispheric model. MATERIALS AND METHODS: The study group consisted of 30 polyps on supine and prone CTC data sets. Measurements were performed separately by two experienced radiologists using the same CTC system (Vitrea 2), resulting in 120 linear and volume measurements. Linear size was defined as the longest dimension among the 2D multiplanar reconstruction views. Semiautomated volume determination required manual tracing of polyp boundaries on 2D multiplanar reconstruction views. The relative error between reviewers 1 and 2 was defined as 100 x (/D1 - D2/)/D(ave) for linear size (D) and as 100 x (/V1 - V2)/V(ave) for volume (V), where ave is average. RESULTS: The mean relative error for linear size and volume measurement was 10.4% +/- 10.7% and 16.9% +/- 13.2%, respectively. Median linear size and volume of polyps were 9.4 mm and 270 mm3, respectively. CTC-derived volumes for medium-sized polyps closely approximated hemispheric volume (V = (pi/12) x D(b), where b =3.13, r2 = 0.90). Small incremental changes in hemispheric size result in a 3:1 relative change in volume versus diameter, such that a 1-mm diameter change in a medium-sized hemispheric polyp results in a relative change in linear size and volume ranging from approximately 11-18% and 31-53%, respectively. CONCLUSION: Because changes in polyp volume are amplified compared with linear dimension, volume measurement rather than diameter measurement will better allow detection of small incremental changes in polyp size using CTC.
Perry J Pickhardt; Vance T Lehman; Thomas C Winter; Andrew J Taylor
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  186     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-22     Completed Date:  2006-06-29     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1605-10     Citation Subset:  AIM; IM    
Department of Radiology, University of Wisconsin Medical School, 600 Highland Ave., Madison, WI 53792, USA.
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MeSH Terms
Colonic Polyps / pathology*,  radiography*
Colonography, Computed Tomographic* / methods
Colorectal Neoplasms / pathology*,  radiography*
Diagnostic Errors
Middle Aged
Population Surveillance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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