Document Detail


Polyostotic Paget's disease. A search for lesions of different durations and for new lesions.
MedLine Citation:
PMID:  9178395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We conducted a medical record-based study of 169 patients with polyostotic involvement identified among 200 Paget's disease patients. Follow-up was 15 to 41 years in 31 cases. The pelvis was the only bone that was more likely than not to be involved bilaterally. All the other paired bones were more likely to be involved unilaterally and when both sides were involved the two lesions were very often frankly asymmetric. In a given patient, the duration of the various pagetic lesions, estimated from their size and from data provided by an earlier study on the rate of progression of pagetic lesions, was similar in some cases and showed marked differences in others. Aggregation of the lesions into two or three disease duration groups was seen in some patients, suggesting that Paget's disease may occur in two or three waves. When we reviewed the radiographs from 30 patients with a mean follow-up of 23 years, we found new lesions in ten patients. However, a review of bone scans from 18 patients with a mean follow-up of 11 years failed to uncover any firm evidence of new lesion development, perhaps because all these patients received bisphosphonate therapy (etidronate, tiludronate, pamidronate). We also found data suggesting that the disease process spread across a joint in some patients, even in the absence of degenerative joint disease. In particular, in several cases an extensive pagetic lesion was seen on one side of a joint and a considerably smaller lesion on the other side.
Authors:
J C Renier; M Audran
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revue du rhumatisme (English ed.)     Volume:  64     ISSN:  1169-8446     ISO Abbreviation:  Rev Rhum Engl Ed     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-25     Completed Date:  1997-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9313916     Medline TA:  Rev Rhum Engl Ed     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  233-42     Citation Subset:  IM    
Affiliation:
Rheumatology Department, Angers Regional Teaching Hospital, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Disease Progression
Female
Fibrous Dysplasia, Polyostotic / radiography*,  radionuclide imaging*
Humans
Male
Middle Aged
Osteitis Deformans / radiography*,  radionuclide imaging*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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