| Polyoma virus-associated nephropathy and concurrent cytomegalovirus infection in the kidney transplant recipients. | |
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MedLine Citation:
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PMID: 16979999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Cytomegalovirus (CMV) and polyoma virus BK (BKV) may both establish latency following primary infection. Frequent reactivation of these viruses can occur in the kidney transplant recipients. BKV may induce CMV gene expression by stimulating cellular regulator proteins or by its own gene regulator proteins. A high rate of concurrent CMV infections has been noted in kidney transplant recipients with polyoma virus-associated nephropathy (PVAN). METHODS: PVAN was identified in 10 of 191 patients who received kidney transplants between October 1998 and September 2003. PVAN was confirmed by allograft kidney biopsy. Four of the 10 patients were complicated by concurrent CMV infection. RESULTS: Two patients had only serological evidence of CMV infection and one patient had CMV gastritis. These three patients were treated with intravenous ganciclovir with good results. Disseminated ganciclovir-resistant CMV disease was demonstrated in the remaining patient. This 34-year-old kidney transplant recipient with PVAN died of multiorgan failure despite antiviral therapy with both ganciclovir and foscarnet. CONCLUSION: PVAN with concurrent CMV infection in kidney transplant recipients showed variable clinical courses including mortality. Further studies are needed to elucidate the influence of PVAN on the pathogenesis of CMV infection. |
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Authors:
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S B Park; J H Kwak; K T Lee; E A Hwang; S Y Han; H T Kim; W H Cho; M S Choi; H C Kim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 38 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-18 Completed Date: 2006-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 2059-61 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Keimyung University School of Medicine, 194 Dong San Dong, Daegu 700-712, Korea. sbpark@dsmc.or.kr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cytomegalovirus / genetics, isolation & purification Cytomegalovirus Infections / complications, epidemiology* Female Gene Expression Regulation, Viral Humans Incidence Kidney Transplantation / pathology* Male Middle Aged Polyomavirus / genetics, isolation & purification Polyomavirus Infections / complications, epidemiology* Postoperative Complications / virology* Retrospective Studies Tissue Donors / statistics & numerical data |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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