| Polyoma tumor development in neonatally polyoma-virus-infected CD4-/- and CD8-/- single knockout and CD4-/-8-/- double knockout mice. | |
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MedLine Citation:
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PMID: 8707416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CD4-/- or CD8-/- single knockout as well as CD4-/-8-/- double knockout mice were infected with polyoma virus as newborns or 1 week after birth. The animals were followed for tumor development and virus persistence. Double knockout mice developed tumors at a higher incidence (29%) than either the CD8-/- or CD4-/- single knockout mice (11% and 2%, respectively). Persistence of polyoma virus was examined by PCR in one third of all animals included in the study. Seven of the 17 CD4-/-8-/- double knockout mice gave positive evidence of virus persistence up to 6 months p.i. where virus DNA was present in most organs. Corresponding tests in single knockout mice gave positive results of persistent viral DNA in 2 of the 19 CD8-/-and 2 of the 7 CD4-/-mice. In the single knockout mice polyoma DNA could only be detected in a more limited variety of organs compared to the double knockouts. |
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Authors:
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Z Berke; T Wen; G Klein; T Dalianis |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 67 ISSN: 0020-7136 ISO Abbreviation: Int. J. Cancer Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-09-10 Completed Date: 1996-09-10 Revised Date: 2007-07-24 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 405-8 Citation Subset: IM; X |
Affiliation:
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Division of Clinical Virology, Karolinska Institute, Huddinge University Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence CD4-Positive T-Lymphocytes / immunology* CD8-Positive T-Lymphocytes / immunology* DNA, Viral / analysis Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Neoplasms, Experimental / immunology*, prevention & control, virology* Papillomavirus Infections / immunology*, prevention & control*, virology Polyomavirus / genetics* Tumor Virus Infections / immunology*, prevention & control*, virology |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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