Document Detail


Polyol pathway in aorta: regulation by hormones.
MedLine Citation:
PMID:  4310476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aldose reductase is present in human and rabbit aortas and provides a mechanism whereby hyper-glycemia can alter the metabolism of the arterial wall. Aortic sorbitol concentration is regulated by ambient glucose concentration and is increased by epinephrine, isoproterenol, dibutyryl-3',5'-adenosine monophosphate, ouabain, and angiotensin II.
Authors:
R S Clements; A D Morrison; A I Winegrad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  166     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1969 Nov 
Date Detail:
Created Date:  1969-12-06     Completed Date:  1969-12-06     Revised Date:  2011-12-07    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1007-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcohol Oxidoreductases / metabolism
Angiotensin II / pharmacology
Animals
Aorta, Thoracic / drug effects,  metabolism*
Cyclic AMP / pharmacology
Epinephrine / pharmacology
Humans
Hyperglycemia / metabolism*
Isoproterenol / pharmacology
Norepinephrine / pharmacology
Ouabain / pharmacology
Rabbits
Sorbitol / metabolism*
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II; 50-70-4/Sorbitol; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 60-92-4/Cyclic AMP; 630-60-4/Ouabain; 7683-59-2/Isoproterenol; EC 1.1.-/Alcohol Oxidoreductases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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