Document Detail

Polyneuropathy in a patient with malignant pleural mesothelioma: a paraneoplastic syndrome.
MedLine Citation:
PMID:  18978574     Owner:  NLM     Status:  MEDLINE    
Paraneoplastic syndromes have only been reported in malignant pleural mesothelioma (MPM) in a few cases. In this case, we describe a 57-year-old man with MPM who developed sensory-motor polyneuropathy 18 days after diagnosis. Thorough endocrinological, neurological, and paraclinical examinations gave no explanation of the symptoms, and paraneoplasia was therefore suspected. The patient was treated with immunoglobulin and prednisolone, and this resulted in subjective, objective, and paraclinical improvement of the symptoms. We therefore suggest that polyneuropathy is a possible paraneoplastic syndrome in MPM.
Cecilia Bech; Jens Benn Sørensen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer     Volume:  3     ISSN:  1556-1380     ISO Abbreviation:  J Thorac Oncol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-03     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101274235     Medline TA:  J Thorac Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1359-60     Citation Subset:  IM    
Department of Oncology, Finsen Centre, National University Hospital, Copenhagen, Denmark.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Carboplatin / administration & dosage
Diagnosis, Differential
Immunoglobulins / therapeutic use
Mesothelioma / complications*,  diagnosis,  therapy
Middle Aged
Paraneoplastic Polyneuropathy / diagnosis*,  drug therapy
Pleural Effusion, Malignant / complications*,  diagnosis,  drug therapy
Prednisolone / administration & dosage
Vinblastine / administration & dosage,  analogs & derivatives
Reg. No./Substance:
0/Immunoglobulins; 41575-94-4/Carboplatin; 50-24-8/Prednisolone; 71486-22-1/vinorelbine; 865-21-4/Vinblastine

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