| Polymyxin B-immobilized fiber hemoperfusion with the PMX-05R column in elderly patients suffering from septic shock. | |
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MedLine Citation:
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PMID: 18030179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Direct hemoperfusion with the polymyxin B-immobilized fiber (PMX-20R) column has a positive effect on outcome in patients with sepsis or septic shock. The PMX-05R column has a low priming volume and has been used in pediatric patients with septic shock. The aim of the present study was to determine whether PMX-F treatment with the PMX-05R column is effective in elderly patients with septic shock. PATIENTS AND METHODS: We performed direct hemoperfusion twice with the PMX-05R column in 8 septic shock patients who were over 80 years of age. Five of the 8 patients survived. The 3 patients who died were undergoing hemodialysis for chronic renal failure, and methicillin-resistant Staphylococcus aureus was detected in all 3. RESULTS: PMX-F treatment significantly increased systolic and diastolic blood pressures (P = 0.0004 for both) and significantly reduced heart rate (P < 0.0001), the blood endotoxin level (P = 0.0011), blood IL-6 level (P = 0.039), C-reactive protein level (P < 0.0001), and white blood cell count (P < 0.0001). CONCLUSIONS: Direct hemoperfusion with the PMX-05R column is effective in ameliorating clinical and laboratory abnormalities in elderly septic shock patients. |
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Authors:
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Tsukasa Nakamura; Yasuhiro Kawagoe; Tsukasa Suzuki; Hisataka Shoji; Yoshihiko Ueda; Hikaru Koide |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 334 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-11-21 Completed Date: 2007-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 244-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged, 80 and over Anti-Bacterial Agents / adverse effects, pharmacology, therapeutic use* Blood Pressure / drug effects C-Reactive Protein / metabolism Dose-Response Relationship, Drug Endotoxins / blood Female Heart Rate / drug effects Hemoperfusion / instrumentation*, methods Humans Interleukin-6 / blood Male Polymyxin B / adverse effects, pharmacology, therapeutic use* Shock, Septic / drug therapy*, metabolism, physiopathology Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Endotoxins; 0/Interleukin-6; 1404-26-8/Polymyxin B; 9007-41-4/C-Reactive Protein |
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