| Polymyositis with respiratory muscle weakness requiring mechanical ventilation in a patient with metastatic thymoma treated with octreotide. | |
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MedLine Citation:
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PMID: 10509161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although most patients with thymoma present with a mediastinal mass amenable to surgical resection, some patients develop metastatic disease requiring systemic therapy. The majority of thymomas express somatostatin receptors as demonstrated by octreotide scanning, an observation which has prompted the clinical use of octreotide in patients with this disease. Many patients with thymoma exhibit autoimmune paraneoplastic syndromes, most frequently myesthenia gravis. We report here the case of a patient with metastatic thymoma who developed a profound autoimmune polymyositis and lupus-like syndrome that flared following treatment with octreotide and was associated with a clinical response to this agent. No evidence for myesthenia gravis was discovered. The severity of the myopathy necessitated mechanical ventilation for 12 weeks. The natural history of thymoma, treatment options including recent combination chemotherapy regimens, and potential mechanisms for flaring of autoimmune paraneoplastic syndromes triggered by therapy of thymoma are discussed. |
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Authors:
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B I Rini; T F Gajewski |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Volume: 10 ISSN: 0923-7534 ISO Abbreviation: Ann. Oncol. Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-11-16 Completed Date: 1999-11-16 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 9007735 Medline TA: Ann Oncol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 973-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Chicago, IL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Antineoplastic Agents, Hormonal / adverse effects*, therapeutic use Antineoplastic Combined Chemotherapy Protocols / therapeutic use Follow-Up Studies Humans Male Muscle Fatigue Octreotide / adverse effects*, therapeutic use Paraneoplastic Syndromes / diagnosis, drug therapy Polymyositis / chemically induced*, therapy Respiration, Artificial Respiratory Muscles / drug effects, pathology* Thymoma / diagnosis, drug therapy*, physiopathology, secondary Thymus Neoplasms / diagnosis, drug therapy*, physiopathology Tracheostomy |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Hormonal; 83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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