Document Detail

Polymyositis-dermatomyositis--a 25-year follow-up of 50 patients (analysis of clinical symptoms and signs and results of laboratory tests).
MedLine Citation:
PMID:  2132428     Owner:  NLM     Status:  MEDLINE    
Clinical symptoms and signs and the frequency of abnormalities in the results of enzymatic, electromyographic, histological and serological tests were analysed in 50 patients, including 17 with polymyositis (PM) and 33 with dermatomyositis (DM), groups I and II according to Bohan's classification and followed-up for 25 years. Weakness of the proximal muscles of the extremities was present in both groups in all patients and in a high proportion of cases weakness involved also the distal muscles. Dysphagia was more frequent in DM patients (54.5%) than in PM (17.6%). In DM erythema and facial oedema as well as Gottron's sign were observed more frequently. In 11.8% of PM patients and 15.1% of DM patients deposition of calcium salts in subcutaneous tissue developed. Signs of vasculitis were found in 39.4% of DM cases and 17.6% of PM cases. In one-third of PM and in only 3 DM cases pitting oedema of the distal parts of the extremities was noted. Cardiovascular changes were disclosed in 82.3% of PM and 69.7% of DM patients. On the other hand, radiological signs of interstitial pulmonary fibrosis were noted more frequently in DM (36%) than in PM (23%). Increased serum activity of CPK, AspAT and ALAT was present with similar frequency in both groups from 71% to 81% of cases. EMG showed evidence of primary muscular changes in all PM patients and 69.6% of DM patients. Histological examination confirmed the diagnosis in the studied patients. Antinuclear antibodies were found relatively rarely, from 2% to 24% of PM/DM patients.(ABSTRACT TRUNCATED AT 250 WORDS)
H Chwalińska-Sadowska; H Małdykowa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Materia medica Polona. Polish journal of medicine and pharmacy     Volume:  22     ISSN:  0025-5246     ISO Abbreviation:  Mater Med Pol     Publication Date:    1990 Jul-Sep
Date Detail:
Created Date:  1992-01-14     Completed Date:  1992-01-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0236526     Medline TA:  Mater Med Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
Department of Connective Tissue Diseases, Institute of Rheumatology, Warszawa, Poland.
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MeSH Terms
Antibodies, Antinuclear / isolation & purification
Dermatomyositis / diagnosis,  physiopathology*
Follow-Up Studies
Myositis / diagnosis,  physiopathology*
Sex Factors
Reg. No./Substance:
0/Antibodies, Antinuclear

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