Document Detail

Polymyalgia rheumatica: a diagnostic challenge in the elderly with haemophilia and diffuse arthropathy.
MedLine Citation:
PMID:  23358205     Owner:  NLM     Status:  In-Data-Review    
With the increased life expectancy and associated comorbidities in haemophilic patients, greater awareness is needed to avoid being misled by symptoms mimicking haemophilia-related conditions. Here, we discuss the case of a 77-year-old man with congenital moderate haemophilia complicated by diffuse haemophilic arthropathy. He presented with persistent pain and stiffness affecting both shoulder and pelvic girdles, unresponsive to factor VIII (FVIII) infusions. A blood test confirmed the high clinical suspicion of polymyalgia rheumatica (PMR), justifying a course of low-dose methylprednisolone that led to significant clinical and biological improvement. This is the first reported case of congenital haemophilia and PMR. We here review some elements helpful to overcome this diagnostic challenge. Adequate diagnosis and management of PMR in elderly patients with haemophilia is particularly important not only to relieve pain but also to avoid inappropriate use of clotting factor concentrates.
Ana Monteiro Carvalhosa; Catherine Lambert; Cedric Hermans
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  24     ISSN:  1473-5733     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  211-2     Citation Subset:  IM    
Haemostasis and Thrombosis Unit, Haemophilia Centre, Division of Haematology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
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