Document Detail

Polymorphonuclear leukocyte adherence and chemotaxis in stressed and healthy neonates.
MedLine Citation:
PMID:  3703618     Owner:  NLM     Status:  MEDLINE    
Defects in polymorphonuclear neutrophil (PMN) adherence and chemotaxis in neonates are thought to be an important cause of their increased susceptibility to overwhelming bacterial infection. Few studies of these functions have been carried out in stressed neonates who are at even greater risk of infection. PMN adherence and chemotaxis were examined in 33 stressed neonates with acute lower respiratory illness, 13 healthy neonates, and 43 healthy adults using whole blood PMN adherence and chemotaxis assays. PMN chemotaxis was significantly decreased in stressed neonates (locomotion index of 38.4 +/- 9.7 micron) compared with that of healthy neonates (48.9 +/- 12.8 micron, p less than 0.01) or adults (61.6 +/- 11.9 micron, p less than 0.001). PMN chemotaxis was studied during illness and recovery in 13 of the 33 stressed neonates and showed significant improvement during recovery (41.6 +/- 9.9 and 53.2 +/- 11.9 micron, respectively, p = 0.012). PMN adherence was decreased in stressed neonates (1.4 +/- 1.6%) compared with that of adults (12.3 +/- 11.4%, p less than 0.01) but was similar to that of healthy neonates (1.1 +/- 1.4%). These findings suggest that further impairment of PMN chemotaxis in stressed neonates helps account for their increased susceptibility to overwhelming bacterial infection.
P J Krause; V C Herson; J Boutin-Lebowitz; L Eisenfeld; C Block; T LoBello; E G Maderazo
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  20     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-02     Completed Date:  1986-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  296-300     Citation Subset:  IM    
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MeSH Terms
Bacterial Infections / etiology
Cell Adhesion
Chemotaxis, Leukocyte*
Heart Defects, Congenital / blood
Infant, Newborn
Neutrophils / physiology*
Pneumonia / blood
Respiratory Distress Syndrome, Newborn / blood
Stress, Physiological / blood*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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