Document Detail

Polymorphonuclear leucocyte locomotion and aggregation in patients with alcoholic liver disease.
MedLine Citation:
PMID:  6509797     Owner:  NLM     Status:  MEDLINE    
Defects in stimulated movement of polymorphonuclear (PMN) leucocytes was detected in 57% of patients with alcoholic liver disease. Serum from patients with the cellular defect had no effect on the function of normal PMN leucocytes. Aggregation responses of patients' PMN leucocytes suggest that the cellular defect may be related to specific abnormalities in the response to the C5a chemotactic factor. Defective serum attractant activity was found in 65% of the patients tested and the presence in the patients serum of humoral directed antagonists appeared to be responsible for the defect in majority of cases. Further analysis pointed to the presence of at least two distinct antagonists and the possible involvement of proteases in this serum abnormality. The activity of the serum antagonists or the severity of the cellular defect were unrelated to the presence of bacterial infection or elevations in serum IgA or IgG. The high frequency of cellular defects, possibly as a result of in vivo activation, in conjunction with serum abnormalities could account for the increased susceptibility of patients with alcoholic liver disease to bacterial infection.
I A Rajkovic; A G Yousif-Kadaru; R J Wyke; R Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  58     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-02-14     Completed Date:  1985-02-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  654-62     Citation Subset:  IM    
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MeSH Terms
Cell Aggregation
Cell Movement
Chemotaxis, Leukocyte
Complement C5
Complement C5a
Liver Diseases, Alcoholic / blood*,  immunology
Middle Aged
N-Formylmethionine Leucyl-Phenylalanine
Neutrophils / physiology*
Reg. No./Substance:
0/Complement C5; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine; 80295-54-1/Complement C5a

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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