| Polymorphonuclear leucocyte locomotion and aggregation in patients with alcoholic liver disease. | |
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MedLine Citation:
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PMID: 6509797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Defects in stimulated movement of polymorphonuclear (PMN) leucocytes was detected in 57% of patients with alcoholic liver disease. Serum from patients with the cellular defect had no effect on the function of normal PMN leucocytes. Aggregation responses of patients' PMN leucocytes suggest that the cellular defect may be related to specific abnormalities in the response to the C5a chemotactic factor. Defective serum attractant activity was found in 65% of the patients tested and the presence in the patients serum of humoral directed antagonists appeared to be responsible for the defect in majority of cases. Further analysis pointed to the presence of at least two distinct antagonists and the possible involvement of proteases in this serum abnormality. The activity of the serum antagonists or the severity of the cellular defect were unrelated to the presence of bacterial infection or elevations in serum IgA or IgG. The high frequency of cellular defects, possibly as a result of in vivo activation, in conjunction with serum abnormalities could account for the increased susceptibility of patients with alcoholic liver disease to bacterial infection. |
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Authors:
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I A Rajkovic; A G Yousif-Kadaru; R J Wyke; R Williams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 58 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-02-14 Completed Date: 1985-02-14 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 654-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cell Aggregation Cell Movement Chemotaxis, Leukocyte Complement C5 Complement C5a Female Humans Liver Diseases, Alcoholic / blood*, immunology Male Middle Aged N-Formylmethionine Leucyl-Phenylalanine Neutrophils / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Complement C5; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine; 80295-54-1/Complement C5a |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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