Document Detail


Polymorphisms of renin-angiotensin system in essential hypertension in Chinese Tibetans.
MedLine Citation:
PMID:  15386947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the potential implications of the genetic variability of angiotensin converting enzyme, angiotensinogen and angiotensin II type 1 receptor gene for essential hypertension in Tibetan. METHODS: A case-control study was conducted in 173 hypertensive individuals and 193 individuals with normal blood pressure. Multiple logistic regression analyses were used to estimate the risks of developing hypertension for different genotypes, and haplotype analyses of the angiotensinogen gene were used to determine the association between two-locus angiotensinogen gene polymorphisms and hypertension. RESULTS: As to the risk to high blood pressure and high systolic pressure, women with MM genotype were 7.7 (95% CI: 1.3-20.5) and 8.7 (95% CI: 1.8-20.1) times higher than those with TT genotype after adjustment for age and body mass index. Haplotype frequencies for M235T and G-6A were significantly different between hypertensive individuals and controls, which indicated an association of angiotensinogen gene haplotypes with hypertension, and a significant association of 235T/-6A haplotype with hypotensive effect. CONCLUSION: Our results suggest that angiotensinogen gene 235MM is a predictor for hypertension development in Tibetan women but not in men, and may exert its hypertensive effect on linkage disequilibrum with a possible function locus of G-6A.
Authors:
Bei Sun; Tsering Dronma; Wei-Jun Qin; Chao-Ying Cui; Dan Tse; Tashi Pingtso; Ying Liu; Chang-Chun Qiu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomedical and environmental sciences : BES     Volume:  17     ISSN:  0895-3988     ISO Abbreviation:  Biomed. Environ. Sci.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-09-24     Completed Date:  2004-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8909524     Medline TA:  Biomed Environ Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  209-16     Citation Subset:  IM    
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100005, China. sunpumc@yahoo.com.cn
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angiotensinogen / genetics
Case-Control Studies
China
DNA / analysis
Female
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Hypertension / genetics*
Male
Middle Aged
Peptidyl-Dipeptidase A / genetics
Polymerase Chain Reaction
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Receptor, Angiotensin, Type 1 / genetics
Renin-Angiotensin System / genetics*
Sex Factors
Tibet / ethnology
Chemical
Reg. No./Substance:
0/Receptor, Angiotensin, Type 1; 11002-13-4/Angiotensinogen; 9007-49-2/DNA; EC 3.4.15.1/Peptidyl-Dipeptidase A

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